TY - JOUR
T1 - Cyclin-dependent kinase 5 is associated with risk for Alzheimer's diseasein a Dutch population-based study
AU - Arias Vasquez, A (Alejandro)
AU - Aulchenko, YS
AU - Isaacs, Aaron
AU - Oosterhout, Andy
AU - Sleegers, K (Kristel)
AU - Hofman, Bert
AU - van Broeckhoven, C
AU - Oostra, Ben
AU - Breteler, Monique
AU - Duijn, Cornelia
PY - 2008
Y1 - 2008
N2 - Although the role of the Cdk5 protein in Alzheimer's disease (AD) is well recognized, there have been relatively few studies investigating genetic variants in the CDK5 gene in AD. In this study, we assessed the association between five previously described single nucleotide polymorphisms (SNPs) in the CDK5 gene and late onset AD by means of logistic regression and haplotype association analyses. Including all prevalent and incident AD cases, we found a significantly increased risk of AD for carriers of the GG genotype of SNP rs2069442 (OR=1.79, 95% CI 1.16-2.79, p = 0.001) in those without APOE*4. When limiting the analysis to incident cases without APOE*4, carriers of the GG genotype showed a 1.9-fold increased risk of AD (95% CI 1.16-3.10, p = 0.003). Variations in the CDK5 gene can be described in 5 haplotype blocks. In our analysis, the haplotype tagged by the G allele of SNP rs2069442 was significantly associated with AD (p = 0.05). In conclusion, our study suggests that CDK5 may be associated with AD.
AB - Although the role of the Cdk5 protein in Alzheimer's disease (AD) is well recognized, there have been relatively few studies investigating genetic variants in the CDK5 gene in AD. In this study, we assessed the association between five previously described single nucleotide polymorphisms (SNPs) in the CDK5 gene and late onset AD by means of logistic regression and haplotype association analyses. Including all prevalent and incident AD cases, we found a significantly increased risk of AD for carriers of the GG genotype of SNP rs2069442 (OR=1.79, 95% CI 1.16-2.79, p = 0.001) in those without APOE*4. When limiting the analysis to incident cases without APOE*4, carriers of the GG genotype showed a 1.9-fold increased risk of AD (95% CI 1.16-3.10, p = 0.003). Variations in the CDK5 gene can be described in 5 haplotype blocks. In our analysis, the haplotype tagged by the G allele of SNP rs2069442 was significantly associated with AD (p = 0.05). In conclusion, our study suggests that CDK5 may be associated with AD.
U2 - 10.1007/s00415-008-0770-5
DO - 10.1007/s00415-008-0770-5
M3 - Article
C2 - 18350355
SN - 0340-5354
VL - 255
SP - 655
EP - 662
JO - Journal of Neurology
JF - Journal of Neurology
IS - 5
ER -