CYP3A5 Genotype Is Not Related to the Intrapatient Variability of Tacrolimus Clearance

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Abstract

Background: The risk of long-term chronic allograft nephropathy and graft loss after kidney transplantation is increased in patients with a high intrapatient variability of tacrolimus (Tac) clearance. Methods: To test whether this intrapatient variability is associated with an individual's CYP3A5 genotype, we measured the intrapatient variability in Tac clearance in a cohort of 208 kidney transplant recipients treated with Tac and mycophenolate mofetil. Results: Tac dose requirement was significantly higher in patients expressing CYP3A5. However, intraindividual variability of Tac clearance was not related to CYP3A5 genotype. Conclusions: Intraindividual variability in Tac clearance is not related to CYP3A5 genotype. Other factors, including patient adherence, may explain the variability in Tac clearance within an individual patient over time.
Original languageEnglish
Pages (from-to)369-371
Number of pages3
JournalTherapeutic Drug Monitoring
Volume33
Issue number3
DOIs
Publication statusPublished - Jun 2011

Research programs

  • EMC MM-01-25-01
  • EMC MM-04-39-05
  • EMC OR-01-34-01

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