Cytogenetics of a malignant ovarian germ-cell tumor

Jannie Van Echten; Lena C. Van Doorn; Hans C. van der Linden; Anneke Y. Van Der Veen; Curt W. Burger; Bauke de Jong

doi:10.1002/(SICI)1097-0215(19980717)77:2<217::AID-IJC8>3.0.CO;2-T

Cytogenetics of a malignant ovarian germ-cell tumor

Jannie Van Echten^*
, Lena C. Van Doorn
, Hans C. van der Linden
, Anneke Y. Van Der Veen
, Curt W. Burger
, Bauke de Jong

^*Corresponding author for this work

University of Groningen
Vrije Universiteit Amsterdam

Research output: Contribution to journal › Article › Academic › peer-review

18 Citations (Scopus)

Abstract

Cytogenetic investigation of a malignant ovarian tumor diagnosed as a mixed germ-cell tumor, composed of extensive choriocarcinoma and loci of yolk-sac tumor, revealed a highly abnormal chromosomal pattern. We found a chromosome number in the hypertriploid/hypotetraploid range, and several clonal structural abnormalities, including 2 copies of an isochromosome 12p. We showed that the chromosomal pattern of this ovarian tumor is very similar to that of testicular germ-cell tumors. This finding, together with reported cytogenetic data of malignant ovarian germ-cell tumors, supports the hypothesis that ovarian and testicular germ-cell tumors are strongly related entities that may have a similar origin and pathogenetic pathway.

Original language	English
Pages (from-to)	217-218
Number of pages	2
Journal	International Journal of Cancer
Volume	77
Issue number	2
DOIs	https://doi.org/10.1002/(SICI)1097-0215(19980717)77:2<217::AID-IJC8>3.0.CO;2-T
Publication status	Published - 17 Jul 1998
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.1002/(SICI)1097-0215(19980717)77:2<217::AID-IJC8>3.0.CO;2-T

Cite this

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title = "Cytogenetics of a malignant ovarian germ-cell tumor",

abstract = "Cytogenetic investigation of a malignant ovarian tumor diagnosed as a mixed germ-cell tumor, composed of extensive choriocarcinoma and loci of yolk-sac tumor, revealed a highly abnormal chromosomal pattern. We found a chromosome number in the hypertriploid/hypotetraploid range, and several clonal structural abnormalities, including 2 copies of an isochromosome 12p. We showed that the chromosomal pattern of this ovarian tumor is very similar to that of testicular germ-cell tumors. This finding, together with reported cytogenetic data of malignant ovarian germ-cell tumors, supports the hypothesis that ovarian and testicular germ-cell tumors are strongly related entities that may have a similar origin and pathogenetic pathway.",

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AU - Van Echten, Jannie

AU - Van Doorn, Lena C.

AU - van der Linden, Hans C.

AU - Van Der Veen, Anneke Y.

AU - Burger, Curt W.

AU - de Jong, Bauke

PY - 1998/7/17

Y1 - 1998/7/17

N2 - Cytogenetic investigation of a malignant ovarian tumor diagnosed as a mixed germ-cell tumor, composed of extensive choriocarcinoma and loci of yolk-sac tumor, revealed a highly abnormal chromosomal pattern. We found a chromosome number in the hypertriploid/hypotetraploid range, and several clonal structural abnormalities, including 2 copies of an isochromosome 12p. We showed that the chromosomal pattern of this ovarian tumor is very similar to that of testicular germ-cell tumors. This finding, together with reported cytogenetic data of malignant ovarian germ-cell tumors, supports the hypothesis that ovarian and testicular germ-cell tumors are strongly related entities that may have a similar origin and pathogenetic pathway.

AB - Cytogenetic investigation of a malignant ovarian tumor diagnosed as a mixed germ-cell tumor, composed of extensive choriocarcinoma and loci of yolk-sac tumor, revealed a highly abnormal chromosomal pattern. We found a chromosome number in the hypertriploid/hypotetraploid range, and several clonal structural abnormalities, including 2 copies of an isochromosome 12p. We showed that the chromosomal pattern of this ovarian tumor is very similar to that of testicular germ-cell tumors. This finding, together with reported cytogenetic data of malignant ovarian germ-cell tumors, supports the hypothesis that ovarian and testicular germ-cell tumors are strongly related entities that may have a similar origin and pathogenetic pathway.

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Cytogenetics of a malignant ovarian germ-cell tumor

Abstract

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