Daptomycin-associated eosinophilic pneumonia in two patients with prosthetic joint infection

Erlangga Yusuf; Nancy Perrottet; Christina Orasch; Olivier Borens; Andrej Trampuz

doi:10.1089/sur.2013.200

Daptomycin-associated eosinophilic pneumonia in two patients with prosthetic joint infection

Erlangga Yusuf^*, Nancy Perrottet, Christina Orasch, Olivier Borens, Andrej Trampuz

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

13 Citations (Scopus)

Abstract

BACKGROUND: Daptomycin is used increasingly to treat prosthetic joint infection (PJI). A possible side effect of this drug is eosinophilic pneumonia. We describe two patients with PJI treated with daptomycin who had this side effect with different clinical presentations.

METHODS: Case reports and review of the literature.

RESULTS: The first case was a 64-year-old male who received daptomycin as a part of the treatment for PJI caused by methicillin-resistant Staphylococcus epidermidis (MRSE). He developed fever without other symptoms; bronchoalveolar lavage (BAL) revealed eosinophils. The second was a 61-year-old male who also used daptomycin as part of the treatment of PJI caused by MRSE and developed severe lung symptoms. Bronchoalveolar lavage and pleural fluid showed an increased number of eosinophils.

CONCLUSION: Daptomycin-induced pneumonia can present with a wide range of symptoms, from fever alone to severe lung symptoms. Surgeons should be aware of this possible side effect when prescribing daptomycin.

Original language	English
Pages (from-to)	834-837
Number of pages	4
Journal	Surgical Infections
Volume	15
Issue number	6
DOIs	https://doi.org/10.1089/sur.2013.200
Publication status	Published - Dec 2014
Externally published	Yes

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title = "Daptomycin-associated eosinophilic pneumonia in two patients with prosthetic joint infection",

abstract = "BACKGROUND: Daptomycin is used increasingly to treat prosthetic joint infection (PJI). A possible side effect of this drug is eosinophilic pneumonia. We describe two patients with PJI treated with daptomycin who had this side effect with different clinical presentations.METHODS: Case reports and review of the literature.RESULTS: The first case was a 64-year-old male who received daptomycin as a part of the treatment for PJI caused by methicillin-resistant Staphylococcus epidermidis (MRSE). He developed fever without other symptoms; bronchoalveolar lavage (BAL) revealed eosinophils. The second was a 61-year-old male who also used daptomycin as part of the treatment of PJI caused by MRSE and developed severe lung symptoms. Bronchoalveolar lavage and pleural fluid showed an increased number of eosinophils.CONCLUSION: Daptomycin-induced pneumonia can present with a wide range of symptoms, from fever alone to severe lung symptoms. Surgeons should be aware of this possible side effect when prescribing daptomycin.",

author = "Erlangga Yusuf and Nancy Perrottet and Christina Orasch and Olivier Borens and Andrej Trampuz",

year = "2014",

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doi = "10.1089/sur.2013.200",

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journal = "Surgical Infections",

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T1 - Daptomycin-associated eosinophilic pneumonia in two patients with prosthetic joint infection

AU - Yusuf, Erlangga

AU - Perrottet, Nancy

AU - Orasch, Christina

AU - Borens, Olivier

AU - Trampuz, Andrej

PY - 2014/12

Y1 - 2014/12

N2 - BACKGROUND: Daptomycin is used increasingly to treat prosthetic joint infection (PJI). A possible side effect of this drug is eosinophilic pneumonia. We describe two patients with PJI treated with daptomycin who had this side effect with different clinical presentations.METHODS: Case reports and review of the literature.RESULTS: The first case was a 64-year-old male who received daptomycin as a part of the treatment for PJI caused by methicillin-resistant Staphylococcus epidermidis (MRSE). He developed fever without other symptoms; bronchoalveolar lavage (BAL) revealed eosinophils. The second was a 61-year-old male who also used daptomycin as part of the treatment of PJI caused by MRSE and developed severe lung symptoms. Bronchoalveolar lavage and pleural fluid showed an increased number of eosinophils.CONCLUSION: Daptomycin-induced pneumonia can present with a wide range of symptoms, from fever alone to severe lung symptoms. Surgeons should be aware of this possible side effect when prescribing daptomycin.

AB - BACKGROUND: Daptomycin is used increasingly to treat prosthetic joint infection (PJI). A possible side effect of this drug is eosinophilic pneumonia. We describe two patients with PJI treated with daptomycin who had this side effect with different clinical presentations.METHODS: Case reports and review of the literature.RESULTS: The first case was a 64-year-old male who received daptomycin as a part of the treatment for PJI caused by methicillin-resistant Staphylococcus epidermidis (MRSE). He developed fever without other symptoms; bronchoalveolar lavage (BAL) revealed eosinophils. The second was a 61-year-old male who also used daptomycin as part of the treatment of PJI caused by MRSE and developed severe lung symptoms. Bronchoalveolar lavage and pleural fluid showed an increased number of eosinophils.CONCLUSION: Daptomycin-induced pneumonia can present with a wide range of symptoms, from fever alone to severe lung symptoms. Surgeons should be aware of this possible side effect when prescribing daptomycin.

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DO - 10.1089/sur.2013.200

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SN - 1096-2964

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SP - 834

EP - 837

JO - Surgical Infections

JF - Surgical Infections

IS - 6

ER -

Daptomycin-associated eosinophilic pneumonia in two patients with prosthetic joint infection

Abstract

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