DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection among Men who Have Sex with Men but not among Injecting Drug Users

Gaby S. Steba; Sylvie M. Koekkoek; Joost W. Vanhommerig; Kees Brinkman; David Kwa; Jan T.M. Van Der Meer; Maria Prins; Ben Berkhout; Michael Tanck; William A. Paxton; Richard Molenkamp; Janke Schinkel

doi:10.1093/infdis/jix587

DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection among Men who Have Sex with Men but not among Injecting Drug Users

Gaby S. Steba
, Sylvie M. Koekkoek
, Joost W. Vanhommerig
, Kees Brinkman
, David Kwa
, Jan T.M. Van Der Meer
, Maria Prins
, Ben Berkhout
, Michael Tanck
, William A. Paxton^*
, Richard Molenkamp
, Janke Schinkel

^*Corresponding author for this work

Amsterdam UMC
Department of Internal Medicine
Onze Lieve Vrouwe Gasthuis
Amsterdam Institute for Infection and Immunology
Municipal Health Service of Amsterdam
University of Liverpool

Research output: Contribution to journal › Article › Academic › peer-review

9 Citations (Scopus)

Abstract

We aimed to identify whether genetic polymorphisms within L-SIGN or DC-SIGN correlate with hepatitis C virus (HCV) susceptibility. A men who have sex with men (MSM) and an injecting drug users (IDU) cohort of HCV cases and multiple-exposed uninfected controls were genotyped for numerous L-SIGN and DC-SIGN polymorphisms. DC-SIGN single nucleotide polymorphisms (SNPs)-139,-871, and-939 correlated with HCV acquisition in the MSM cohort only. When the same SNPs were introduced into a transcription activity assay they demonstrated a reduction in expression with predicted alteration in binding of transcription factors. DC-SIGN promoter SNPs correlated with risk of HCV acquisition via sexual but not IDU exposure, likely through modulation of mRNA expression levels.

Original language	English
Pages (from-to)	353-357
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	217
Issue number	3
DOIs	https://doi.org/10.1093/infdis/jix587
Publication status	Published - 1 Feb 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017 The Author(s).

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection Among Men who Have Sex with Men but not Among Injecting Drug UsersFinal published version, 263 KBLicence: CC BY

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Steba, G. S., Koekkoek, S. M., Vanhommerig, J. W., Brinkman, K., Kwa, D., Van Der Meer, J. T. M., Prins, M., Berkhout, B., Tanck, M., Paxton, W. A., Molenkamp, R., & Schinkel, J. (2018). DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection among Men who Have Sex with Men but not among Injecting Drug Users. Journal of Infectious Diseases, 217(3), 353-357. https://doi.org/10.1093/infdis/jix587

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title = "DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection among Men who Have Sex with Men but not among Injecting Drug Users",

abstract = "We aimed to identify whether genetic polymorphisms within L-SIGN or DC-SIGN correlate with hepatitis C virus (HCV) susceptibility. A men who have sex with men (MSM) and an injecting drug users (IDU) cohort of HCV cases and multiple-exposed uninfected controls were genotyped for numerous L-SIGN and DC-SIGN polymorphisms. DC-SIGN single nucleotide polymorphisms (SNPs)-139,-871, and-939 correlated with HCV acquisition in the MSM cohort only. When the same SNPs were introduced into a transcription activity assay they demonstrated a reduction in expression with predicted alteration in binding of transcription factors. DC-SIGN promoter SNPs correlated with risk of HCV acquisition via sexual but not IDU exposure, likely through modulation of mRNA expression levels.",

author = "Steba, \{Gaby S.\} and Koekkoek, \{Sylvie M.\} and Vanhommerig, \{Joost W.\} and Kees Brinkman and David Kwa and \{Van Der Meer\}, \{Jan T.M.\} and Maria Prins and Ben Berkhout and Michael Tanck and Paxton, \{William A.\} and Richard Molenkamp and Janke Schinkel",

note = "Publisher Copyright: {\textcopyright} 2017 The Author(s).",

year = "2018",

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day = "1",

doi = "10.1093/infdis/jix587",

language = "English",

volume = "217",

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Steba, GS, Koekkoek, SM, Vanhommerig, JW, Brinkman, K, Kwa, D, Van Der Meer, JTM, Prins, M, Berkhout, B, Tanck, M, Paxton, WA, Molenkamp, R & Schinkel, J 2018, 'DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection among Men who Have Sex with Men but not among Injecting Drug Users', Journal of Infectious Diseases, vol. 217, no. 3, pp. 353-357. https://doi.org/10.1093/infdis/jix587

TY - JOUR

T1 - DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection among Men who Have Sex with Men but not among Injecting Drug Users

AU - Steba, Gaby S.

AU - Koekkoek, Sylvie M.

AU - Vanhommerig, Joost W.

AU - Brinkman, Kees

AU - Kwa, David

AU - Van Der Meer, Jan T.M.

AU - Prins, Maria

AU - Berkhout, Ben

AU - Tanck, Michael

AU - Paxton, William A.

AU - Molenkamp, Richard

AU - Schinkel, Janke

PY - 2018/2/1

Y1 - 2018/2/1

N2 - We aimed to identify whether genetic polymorphisms within L-SIGN or DC-SIGN correlate with hepatitis C virus (HCV) susceptibility. A men who have sex with men (MSM) and an injecting drug users (IDU) cohort of HCV cases and multiple-exposed uninfected controls were genotyped for numerous L-SIGN and DC-SIGN polymorphisms. DC-SIGN single nucleotide polymorphisms (SNPs)-139,-871, and-939 correlated with HCV acquisition in the MSM cohort only. When the same SNPs were introduced into a transcription activity assay they demonstrated a reduction in expression with predicted alteration in binding of transcription factors. DC-SIGN promoter SNPs correlated with risk of HCV acquisition via sexual but not IDU exposure, likely through modulation of mRNA expression levels.

AB - We aimed to identify whether genetic polymorphisms within L-SIGN or DC-SIGN correlate with hepatitis C virus (HCV) susceptibility. A men who have sex with men (MSM) and an injecting drug users (IDU) cohort of HCV cases and multiple-exposed uninfected controls were genotyped for numerous L-SIGN and DC-SIGN polymorphisms. DC-SIGN single nucleotide polymorphisms (SNPs)-139,-871, and-939 correlated with HCV acquisition in the MSM cohort only. When the same SNPs were introduced into a transcription activity assay they demonstrated a reduction in expression with predicted alteration in binding of transcription factors. DC-SIGN promoter SNPs correlated with risk of HCV acquisition via sexual but not IDU exposure, likely through modulation of mRNA expression levels.

UR - https://www.scopus.com/pages/publications/85041170330

U2 - 10.1093/infdis/jix587

DO - 10.1093/infdis/jix587

M3 - Article

C2 - 29140443

AN - SCOPUS:85041170330

SN - 0022-1899

VL - 217

SP - 353

EP - 357

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 3

ER -

DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection among Men who Have Sex with Men but not among Injecting Drug Users

Abstract

Bibliographical note

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