De invloed van immunoscintigrafie met monoklonale antilichamen op bepalingen van hormonen en tumormerkstoffen: Een muis met een staartje.

Translated title of the contribution: Effect of immunoscintigraphy with monoclonal antibodies in assays of hormones and tumour markers.: Beware of a mouse-trap!

J. A.M.J.L. Janssen, P. J. Blankestijn, R. Docter, B. G. Blijenberg, S. W.J. Lamberts, E. P. Krenning*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The use of monoclonal antibodies in medicine for in-vivo diagnostic methods and for therapeutic purposes will increase in the future. Although monoclonal antibodies possess a high specificity, the animal origin of these antibodies remains a problem. Repeated administration of animal monoclonal antibodies (in vivo) may induce the formation of human antibodies against these monoclonal antibodies. Because animal monoclonal antibodies are also used in laboratory assays (in vitro), the presence of human antibodies against these animal monoclonal antibodies may cause spuriously elevated or depressed results of these assays. The clinician should be alert to this possibility. A case history is presented to demonstrate the problem.

Translated title of the contributionEffect of immunoscintigraphy with monoclonal antibodies in assays of hormones and tumour markers.: Beware of a mouse-trap!
Original languageDutch
Pages (from-to)1455-1458
Number of pages4
JournalNederlands Tijdschrift voor Geneeskunde
Volume133
Issue number29
Publication statusPublished - 22 Jul 1989

Bibliographical note

Dit artikel werd eerder gepubliceerd met als titel "Effects of immunoscintigraphy with monoclonal antibodies in assays of hormones and tumour markers" in Br.Med.J. 1889, 298: 1511-3

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