Declining Prevalence of HIV-1 Drug Resistance in Antiretroviral Treatment-exposed Individuals in Western Europe

A Luca; D Dunn; M Zazzi; R Camacho; C Torti; I Fanti; R Kaiser; A Sonnerborg; FM Codoner; K Van Laethem; AM Vandamme; L Bansi; V Ghisetti; David van de Vijver; D Asboe; MCF Prosperi; S Di Giambenedetto

doi:10.1093/infdis/jit017

Declining Prevalence of HIV-1 Drug Resistance in Antiretroviral Treatment-exposed Individuals in Western Europe

A Luca, D Dunn, M Zazzi, R Camacho, C Torti, I Fanti, R Kaiser, A Sonnerborg, FM Codoner, K Van Laethem, AM Vandamme, L Bansi, V Ghisetti, David van de Vijver, D Asboe, MCF Prosperi, S Di Giambenedetto

Virology

Research output: Contribution to journal › Article › Academic › peer-review

59 Citations (Scopus)

Abstract

HIV-1 drug resistance represents a major obstacle to infection and disease control. This retrospective study analyzes trends and determinants of resistance in antiretroviral treatment (ART)-exposed individuals across 7 countries in Europe. Of 20 323 cases, 80% carried at least one resistance mutation: these declined from 81% in 1997 to 71% in 2008. Predicted extensive 3-class resistance was rare (3.2% considering the cumulative genotype) and peaked at 4.5% in 2005, decreasing thereafter. The proportion of cases exhausting available drug options dropped from 32% in 2000 to 1% in 2008. Reduced risk of resistance over calendar years was confirmed by multivariable analysis.

Original language	Undefined/Unknown
Pages (from-to)	1216-1220
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	207
Issue number	8
DOIs	https://doi.org/10.1093/infdis/jit017
Publication status	Published - 2013

Research programs

EMC MM-04-27-01

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/infdis/jit017

http://hdl.handle.net/1765/64834

Cite this

Luca, A., Dunn, D., Zazzi, M., Camacho, R., Torti, C., Fanti, I., Kaiser, R., Sonnerborg, A., Codoner, FM., Van Laethem, K., Vandamme, AM., Bansi, L., Ghisetti, V., van de Vijver, D., Asboe, D., Prosperi, MCF., & Di Giambenedetto, S. (2013). Declining Prevalence of HIV-1 Drug Resistance in Antiretroviral Treatment-exposed Individuals in Western Europe. Journal of Infectious Diseases, 207(8), 1216-1220. https://doi.org/10.1093/infdis/jit017

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Luca, A, Dunn, D, Zazzi, M, Camacho, R, Torti, C, Fanti, I, Kaiser, R, Sonnerborg, A, Codoner, FM, Van Laethem, K, Vandamme, AM, Bansi, L, Ghisetti, V, van de Vijver, D, Asboe, D, Prosperi, MCF & Di Giambenedetto, S 2013, 'Declining Prevalence of HIV-1 Drug Resistance in Antiretroviral Treatment-exposed Individuals in Western Europe', Journal of Infectious Diseases, vol. 207, no. 8, pp. 1216-1220. https://doi.org/10.1093/infdis/jit017

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AU - Luca, A

AU - Dunn, D

AU - Zazzi, M

AU - Camacho, R

AU - Torti, C

AU - Fanti, I

AU - Kaiser, R

AU - Sonnerborg, A

AU - Codoner, FM

AU - Van Laethem, K

AU - Vandamme, AM

AU - Bansi, L

AU - Ghisetti, V

AU - van de Vijver, David

AU - Asboe, D

AU - Prosperi, MCF

AU - Di Giambenedetto, S

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AB - HIV-1 drug resistance represents a major obstacle to infection and disease control. This retrospective study analyzes trends and determinants of resistance in antiretroviral treatment (ART)-exposed individuals across 7 countries in Europe. Of 20 323 cases, 80% carried at least one resistance mutation: these declined from 81% in 1997 to 71% in 2008. Predicted extensive 3-class resistance was rare (3.2% considering the cumulative genotype) and peaked at 4.5% in 2005, decreasing thereafter. The proportion of cases exhausting available drug options dropped from 32% in 2000 to 1% in 2008. Reduced risk of resistance over calendar years was confirmed by multivariable analysis.

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