Decreased activity and stability of pyruvate kinase in sickle cell disease: a novel target for mitapivat therapy

Minke A. E. Rab; Jennifer Bos; Brigitte A. van Oirschot; H.A.S. (Stéphanie) van Straaten; Penelope A. Kosinski; Victor Chubukov; Hyeryun Kim; Heidi Mangus; Roger E. G. Schutgens; Gerard Pasterkamp; Lenny Dang; Charles Kung; Eduard J. van Beers; Richard van Wijk

doi:10.1182/blood.2020008635

Decreased activity and stability of pyruvate kinase in sickle cell disease: a novel target for mitapivat therapy

Minke A. E. Rab
, Jennifer Bos
, Brigitte A. van Oirschot
, H.A.S. (Stéphanie) van Straaten
, Penelope A. Kosinski
, Victor Chubukov
, Hyeryun Kim
, Heidi Mangus
, Roger E. G. Schutgens
, Gerard Pasterkamp
, Lenny Dang
, Charles Kung
, Eduard J. van Beers
, Richard van Wijk^*

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

38 Citations (Web of Science)

112 Downloads (Pure)

Original language	English
Pages (from-to)	2997-3001
Number of pages	5
Journal	Blood
Volume	137
Issue number	21
DOIs	https://doi.org/10.1182/blood.2020008635
Publication status	Published - 27 May 2021

Bibliographical note

Funding Information:
This research has been funded, in part, by Agios Pharmaceuticals Inc and the Eurostars Program (SCOOP, ESTAR18105).

Research programs

EMC MM-02-54-03

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Cite this

Rab, M. A. E., Bos, J., van Oirschot, B. A., van Straaten, H. A. S., Kosinski, P. A., Chubukov, V., Kim, H., Mangus, H., Schutgens, R. E. G., Pasterkamp, G., Dang, L., Kung, C., van Beers, E. J., & van Wijk, R. (2021). Decreased activity and stability of pyruvate kinase in sickle cell disease: a novel target for mitapivat therapy. Blood, 137(21), 2997-3001. https://doi.org/10.1182/blood.2020008635

@article{4acb10d9e28348569895ebeffb828213,

title = "Decreased activity and stability of pyruvate kinase in sickle cell disease: a novel target for mitapivat therapy",

author = "Rab, \{Minke A. E.\} and Jennifer Bos and \{van Oirschot\}, \{Brigitte A.\} and \{van Straaten\}, \{H.A.S. (St{\'e}phanie)\} and Kosinski, \{Penelope A.\} and Victor Chubukov and Hyeryun Kim and Heidi Mangus and Schutgens, \{Roger E. G.\} and Gerard Pasterkamp and Lenny Dang and Charles Kung and \{van Beers\}, \{Eduard J.\} and \{van Wijk\}, Richard",

note = "Funding Information: This research has been funded, in part, by Agios Pharmaceuticals Inc and the Eurostars Program (SCOOP, ESTAR18105).",

year = "2021",

month = may,

day = "27",

doi = "10.1182/blood.2020008635",

language = "English",

volume = "137",

pages = "2997--3001",

journal = "Blood",

issn = "0006-4971",

publisher = "Elsevier",

number = "21",

}

Rab, MAE, Bos, J, van Oirschot, BA, van Straaten, HAS, Kosinski, PA, Chubukov, V, Kim, H, Mangus, H, Schutgens, REG, Pasterkamp, G, Dang, L, Kung, C, van Beers, EJ & van Wijk, R 2021, 'Decreased activity and stability of pyruvate kinase in sickle cell disease: a novel target for mitapivat therapy', Blood, vol. 137, no. 21, pp. 2997-3001. https://doi.org/10.1182/blood.2020008635

TY - JOUR

T1 - Decreased activity and stability of pyruvate kinase in sickle cell disease: a novel target for mitapivat therapy

AU - Rab, Minke A. E.

AU - Bos, Jennifer

AU - van Oirschot, Brigitte A.

AU - van Straaten, H.A.S. (Stéphanie)

AU - Kosinski, Penelope A.

AU - Chubukov, Victor

AU - Kim, Hyeryun

AU - Mangus, Heidi

AU - Schutgens, Roger E. G.

AU - Pasterkamp, Gerard

AU - Dang, Lenny

AU - Kung, Charles

AU - van Beers, Eduard J.

AU - van Wijk, Richard

N1 - Funding Information: This research has been funded, in part, by Agios Pharmaceuticals Inc and the Eurostars Program (SCOOP, ESTAR18105).

PY - 2021/5/27

Y1 - 2021/5/27

U2 - 10.1182/blood.2020008635

DO - 10.1182/blood.2020008635

M3 - Comment/Letter to the editor

C2 - 33690814

SN - 0006-4971

VL - 137

SP - 2997

EP - 3001

JO - Blood

JF - Blood

IS - 21

ER -