TY - JOUR
T1 - Defining remission in childhood-onset lupus
T2 - PReS-endorsed consensus definitions by an international task force
AU - Smith, E. M.D.
AU - Aggarwal, A.
AU - Ainsworth, J.
AU - the International cSLE T2T Task Force
AU - Al-Abadi, E.
AU - Avcin, T.
AU - Bortey, L.
AU - Burnham, J.
AU - Ciurtin, C.
AU - Hedrich, C. M.
AU - Kamphuis, S.
AU - Lambert, L.
AU - Levy, D. M.
AU - Lewandowski, L.
AU - Maxwell, N.
AU - Morand, E.
AU - Özen, S.
AU - Pain, C. E.
AU - Ravelli, A.
AU - Saad Magalhaes, C.
AU - Pilkington, C.
AU - Schonenberg-Meinema, D.
AU - Scott, C.
AU - Tullus, K.
AU - Beresford, M. W.
AU - Goilav, B.
AU - Goss, N.
AU - Oni, L.
AU - Marks, S. D.
N1 - Publisher Copyright:
© 2024 The Authors
PY - 2024/6
Y1 - 2024/6
N2 - Objective: To derive childhood-onset SLE (cSLE) specific remission definitions for future treat-to-target (T2T) trials, observational studies, and clinical practice. Methods: The cSLE International T2T Task Force conducted Delphi surveys exploring paediatric perspectives on adult-onset SLE remission targets. A modified nominal group technique was used to discuss, refine, and agree on the cSLE remission target criteria.Results: The Task Force proposed two definitions of remission: ‘cSLE clinical remission on steroids (cCR)’ and ‘cSLE clinical remission off steroids (cCR-0)’. The common criteria are: (1) Clinical-SLEDAI-2 K = 0; (2) PGA score < 0.5 (0–3 scale); (4) stable antimalarials, immunosuppressive, and biologic therapy (changes due to side-effects, adherence, weight, or when building up to target dose allowed). Criterion (3) in cCR is the prednisolone dose ≤0.1 mg/kg/day (maximum 5 mg/day), whereas in cCR-0 it is zero. Conclusions: cSLE definitions of remission have been proposed, maintaining sufficient alignment with the adult-SLE definition to facilitate life-course research.
AB - Objective: To derive childhood-onset SLE (cSLE) specific remission definitions for future treat-to-target (T2T) trials, observational studies, and clinical practice. Methods: The cSLE International T2T Task Force conducted Delphi surveys exploring paediatric perspectives on adult-onset SLE remission targets. A modified nominal group technique was used to discuss, refine, and agree on the cSLE remission target criteria.Results: The Task Force proposed two definitions of remission: ‘cSLE clinical remission on steroids (cCR)’ and ‘cSLE clinical remission off steroids (cCR-0)’. The common criteria are: (1) Clinical-SLEDAI-2 K = 0; (2) PGA score < 0.5 (0–3 scale); (4) stable antimalarials, immunosuppressive, and biologic therapy (changes due to side-effects, adherence, weight, or when building up to target dose allowed). Criterion (3) in cCR is the prednisolone dose ≤0.1 mg/kg/day (maximum 5 mg/day), whereas in cCR-0 it is zero. Conclusions: cSLE definitions of remission have been proposed, maintaining sufficient alignment with the adult-SLE definition to facilitate life-course research.
UR - https://www.scopus.com/pages/publications/85191445420
U2 - 10.1016/j.clim.2024.110214
DO - 10.1016/j.clim.2024.110214
M3 - Article
C2 - 38604255
AN - SCOPUS:85191445420
SN - 1521-6616
VL - 263
JO - Clinical Immunology
JF - Clinical Immunology
M1 - 110214
ER -