Delayed gadolinium-enhanced MRI of the meniscus (dGEMRIM) in patients with knee osteoarthritis: relation with meniscal degeneration on conventional MRI, reproducibility, and correlation with dGEMRIC

Jasper Tiel; Gyula Kotek; Max Reijman; Koen Bos; Esther Bron; Stefan Klein; Jan Verhaar; Gabriel Krestin; HH Weinans; Edwin Oei

doi:10.1007/s00330-014-3204-z

Delayed gadolinium-enhanced MRI of the meniscus (dGEMRIM) in patients with knee osteoarthritis: relation with meniscal degeneration on conventional MRI, reproducibility, and correlation with dGEMRIC

Jasper Tiel, Gyula Kotek, Max Reijman, Koen Bos, Esther Bron, Stefan Klein, Jan Verhaar, Gabriel Krestin, HH Weinans, Edwin Oei

Research output: Contribution to journal › Article › Academic › peer-review

17 Citations (Scopus)

Abstract

To assess (1) whether normal and degenerated menisci exhibit different T1(GD) on delayed gadolinium-enhanced MRI of the meniscus (dGEMRIM), (2) the reproducibility of dGEMRIM and (3) the correlation between meniscus and cartilage T1(GD) in knee osteoarthritis (OA) patients. In 17 OA patients who underwent dGEMRIM twice within 7 days, meniscus and cartilage T1(GD) was calculated. Meniscus pathology was evaluated on conventional MRI. T1(GD) in normal and degenerated menisci were compared using a Student's t-test. Reproducibility was assessed using ICCs. Pearson's correlation was calculated between meniscus and cartilage T1(GD). A trend towards lower T1(GD) in degenerated menisci (mean: 402 ms; 95 % CI: 359-444 ms) compared to normal menisci (mean: 448 ms; 95 % CI: 423-473 ms) was observed (p = 0.05). Meniscus T1(GD) ICCs were 0.85-0.90. The correlation between meniscus and cartilage T1(GD) was moderate in the lateral (r = 0.52-0.75) and strong in the medial compartment (r = 0.78-0.94). Our results show that degenerated menisci have a clear trend towards lower T1(GD) compared to normal menisci. Since these results are highly reproducible, meniscus degeneration may be assessed within one delayed gadolinium-enhanced MRI simultaneously with cartilage. The strong correlation between meniscus and cartilage T1(GD) suggests concomitant degeneration in both tissues in OA, but also suggests that dGEMRIC may not be regarded entirely as sulphated glycosaminoglycan specific. aEuro cent dGEMRIM T1 (GD) can possibly be used to assess meniscal degeneration; aEuro cent dGEMRIM yields highly reproducible meniscal T1 (GD) in early stage osteoarthritic patients; aEuro cent Concomitant degeneration of cartilage and meniscus tissue occurs in early stage osteoarthritis; aEuro cent dGEMRIC cannot be regarded as entirely sulphated glycosaminoglycan specific.

Original language	Undefined/Unknown
Pages (from-to)	2261-2270
Number of pages	10
Journal	European Radiology
Volume	24
Issue number	9
DOIs	https://doi.org/10.1007/s00330-014-3204-z
Publication status	Published - 2014

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10.1007/s00330-014-3204-z

http://hdl.handle.net/1765/61244

Cite this

Tiel, J., Kotek, G., Reijman, M., Bos, K., Bron, E., Klein, S., Verhaar, J., Krestin, G., Weinans, HH., & Oei, E. (2014). Delayed gadolinium-enhanced MRI of the meniscus (dGEMRIM) in patients with knee osteoarthritis: relation with meniscal degeneration on conventional MRI, reproducibility, and correlation with dGEMRIC. European Radiology, 24(9), 2261-2270. https://doi.org/10.1007/s00330-014-3204-z

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title = "Delayed gadolinium-enhanced MRI of the meniscus (dGEMRIM) in patients with knee osteoarthritis: relation with meniscal degeneration on conventional MRI, reproducibility, and correlation with dGEMRIC",

abstract = "To assess (1) whether normal and degenerated menisci exhibit different T1(GD) on delayed gadolinium-enhanced MRI of the meniscus (dGEMRIM), (2) the reproducibility of dGEMRIM and (3) the correlation between meniscus and cartilage T1(GD) in knee osteoarthritis (OA) patients. In 17 OA patients who underwent dGEMRIM twice within 7 days, meniscus and cartilage T1(GD) was calculated. Meniscus pathology was evaluated on conventional MRI. T1(GD) in normal and degenerated menisci were compared using a Student's t-test. Reproducibility was assessed using ICCs. Pearson's correlation was calculated between meniscus and cartilage T1(GD). A trend towards lower T1(GD) in degenerated menisci (mean: 402 ms; 95 % CI: 359-444 ms) compared to normal menisci (mean: 448 ms; 95 % CI: 423-473 ms) was observed (p = 0.05). Meniscus T1(GD) ICCs were 0.85-0.90. The correlation between meniscus and cartilage T1(GD) was moderate in the lateral (r = 0.52-0.75) and strong in the medial compartment (r = 0.78-0.94). Our results show that degenerated menisci have a clear trend towards lower T1(GD) compared to normal menisci. Since these results are highly reproducible, meniscus degeneration may be assessed within one delayed gadolinium-enhanced MRI simultaneously with cartilage. The strong correlation between meniscus and cartilage T1(GD) suggests concomitant degeneration in both tissues in OA, but also suggests that dGEMRIC may not be regarded entirely as sulphated glycosaminoglycan specific. aEuro cent dGEMRIM T1 (GD) can possibly be used to assess meniscal degeneration; aEuro cent dGEMRIM yields highly reproducible meniscal T1 (GD) in early stage osteoarthritic patients; aEuro cent Concomitant degeneration of cartilage and meniscus tissue occurs in early stage osteoarthritis; aEuro cent dGEMRIC cannot be regarded as entirely sulphated glycosaminoglycan specific.",

author = "Jasper Tiel and Gyula Kotek and Max Reijman and Koen Bos and Esther Bron and Stefan Klein and Jan Verhaar and Gabriel Krestin and HH Weinans and Edwin Oei",

year = "2014",

doi = "10.1007/s00330-014-3204-z",

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Tiel, J, Kotek, G , Reijman, M , Bos, K , Bron, E , Klein, S , Verhaar, J , Krestin, G, Weinans, HH & Oei, E 2014, 'Delayed gadolinium-enhanced MRI of the meniscus (dGEMRIM) in patients with knee osteoarthritis: relation with meniscal degeneration on conventional MRI, reproducibility, and correlation with dGEMRIC', European Radiology, vol. 24, no. 9, pp. 2261-2270. https://doi.org/10.1007/s00330-014-3204-z

Delayed gadolinium-enhanced MRI of the meniscus (dGEMRIM) in patients with knee osteoarthritis: relation with meniscal degeneration on conventional MRI, reproducibility, and correlation with dGEMRIC. / Tiel, Jasper; Kotek, Gyula ; Reijman, Max et al.

In: European Radiology, Vol. 24, No. 9, 2014, p. 2261-2270.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Delayed gadolinium-enhanced MRI of the meniscus (dGEMRIM) in patients with knee osteoarthritis: relation with meniscal degeneration on conventional MRI, reproducibility, and correlation with dGEMRIC

AU - Tiel, Jasper

AU - Kotek, Gyula

AU - Reijman, Max

AU - Bos, Koen

AU - Bron, Esther

AU - Klein, Stefan

AU - Verhaar, Jan

AU - Krestin, Gabriel

AU - Weinans, HH

AU - Oei, Edwin

PY - 2014

Y1 - 2014

N2 - To assess (1) whether normal and degenerated menisci exhibit different T1(GD) on delayed gadolinium-enhanced MRI of the meniscus (dGEMRIM), (2) the reproducibility of dGEMRIM and (3) the correlation between meniscus and cartilage T1(GD) in knee osteoarthritis (OA) patients. In 17 OA patients who underwent dGEMRIM twice within 7 days, meniscus and cartilage T1(GD) was calculated. Meniscus pathology was evaluated on conventional MRI. T1(GD) in normal and degenerated menisci were compared using a Student's t-test. Reproducibility was assessed using ICCs. Pearson's correlation was calculated between meniscus and cartilage T1(GD). A trend towards lower T1(GD) in degenerated menisci (mean: 402 ms; 95 % CI: 359-444 ms) compared to normal menisci (mean: 448 ms; 95 % CI: 423-473 ms) was observed (p = 0.05). Meniscus T1(GD) ICCs were 0.85-0.90. The correlation between meniscus and cartilage T1(GD) was moderate in the lateral (r = 0.52-0.75) and strong in the medial compartment (r = 0.78-0.94). Our results show that degenerated menisci have a clear trend towards lower T1(GD) compared to normal menisci. Since these results are highly reproducible, meniscus degeneration may be assessed within one delayed gadolinium-enhanced MRI simultaneously with cartilage. The strong correlation between meniscus and cartilage T1(GD) suggests concomitant degeneration in both tissues in OA, but also suggests that dGEMRIC may not be regarded entirely as sulphated glycosaminoglycan specific. aEuro cent dGEMRIM T1 (GD) can possibly be used to assess meniscal degeneration; aEuro cent dGEMRIM yields highly reproducible meniscal T1 (GD) in early stage osteoarthritic patients; aEuro cent Concomitant degeneration of cartilage and meniscus tissue occurs in early stage osteoarthritis; aEuro cent dGEMRIC cannot be regarded as entirely sulphated glycosaminoglycan specific.

AB - To assess (1) whether normal and degenerated menisci exhibit different T1(GD) on delayed gadolinium-enhanced MRI of the meniscus (dGEMRIM), (2) the reproducibility of dGEMRIM and (3) the correlation between meniscus and cartilage T1(GD) in knee osteoarthritis (OA) patients. In 17 OA patients who underwent dGEMRIM twice within 7 days, meniscus and cartilage T1(GD) was calculated. Meniscus pathology was evaluated on conventional MRI. T1(GD) in normal and degenerated menisci were compared using a Student's t-test. Reproducibility was assessed using ICCs. Pearson's correlation was calculated between meniscus and cartilage T1(GD). A trend towards lower T1(GD) in degenerated menisci (mean: 402 ms; 95 % CI: 359-444 ms) compared to normal menisci (mean: 448 ms; 95 % CI: 423-473 ms) was observed (p = 0.05). Meniscus T1(GD) ICCs were 0.85-0.90. The correlation between meniscus and cartilage T1(GD) was moderate in the lateral (r = 0.52-0.75) and strong in the medial compartment (r = 0.78-0.94). Our results show that degenerated menisci have a clear trend towards lower T1(GD) compared to normal menisci. Since these results are highly reproducible, meniscus degeneration may be assessed within one delayed gadolinium-enhanced MRI simultaneously with cartilage. The strong correlation between meniscus and cartilage T1(GD) suggests concomitant degeneration in both tissues in OA, but also suggests that dGEMRIC may not be regarded entirely as sulphated glycosaminoglycan specific. aEuro cent dGEMRIM T1 (GD) can possibly be used to assess meniscal degeneration; aEuro cent dGEMRIM yields highly reproducible meniscal T1 (GD) in early stage osteoarthritic patients; aEuro cent Concomitant degeneration of cartilage and meniscus tissue occurs in early stage osteoarthritis; aEuro cent dGEMRIC cannot be regarded as entirely sulphated glycosaminoglycan specific.

U2 - 10.1007/s00330-014-3204-z

DO - 10.1007/s00330-014-3204-z

M3 - Article

SN - 0938-7994

VL - 24

SP - 2261

EP - 2270

JO - European Radiology

JF - European Radiology

IS - 9

ER -