Delirium in the Acute Phase After Stroke and the Role of the Apolipoprotein E Gene

AW Oldenbeuving, PLM de Kort, LJ Kappelle, Cornelia Duijn, G Roks

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14 Citations (Scopus)

Abstract

Objective: To study the association between the epsilon 4 allele of apolipoprotein E (APOE epsilon 4) and delirium in a stroke population. Methods: 527 consecutive stroke patients were screened for delirium during the first week of admission with the confusion assessment method. In three hundred fifty-three patients genomic DNA isolation was available. Results: The incidence of delirium after stroke in the 353 patients was 11.3%. There was no association between APOE epsilon 4 and delirium. Even after adjustment for IQCODE, stroke localization, stroke subtype, stroke severity, infection, and brain atrophy no association was found (odds ratio: 0.9; 95% confidence interval: 0.4-2.1). Delirium did not last longer in patients with an APOE epsilon 4 allele compared to patients without an APOE epsilon 4 allele (median: 5.6 days [range: 1-21] versus median: 4.6 days [range: 1-15], p = 0.5). Conclusion: There was no association between the presence of an APOE epsilon 4 allele and the occurrence of delirium in the acute phase after stroke.
Original languageUndefined/Unknown
Pages (from-to)935-937
Number of pages3
JournalAmerican Journal of Geriatric Psychiatry
Volume21
Issue number10
DOIs
Publication statusPublished - 2013

Research programs

  • EMC NIHES-01-64-01

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