TY - JOUR
T1 - Design and implementation of multicenter pediatric and congenital studies with cardiovascular magnetic resonance
T2 - Big data in smaller bodies
AU - DiLorenzo, Michael P.
AU - Lee, Simon
AU - Rathod, Rahul H.
AU - Raimondi, Francesca
AU - Farooqi, Kanwal M.
AU - Jain, Supriya S.
AU - Samyn, Margaret M.
AU - Johnson, Tiffanie R.
AU - Olivieri, Laura J.
AU - Fogel, Mark A.
AU - Lai, Wyman W.
AU - Renella, Pierangelo
AU - Powell, Andrew J.
AU - Buddhe, Sujatha
AU - Stafford, Caitlin
AU - Johnson, Jason N.
AU - Helbing, Willem A.
AU - Pushparajah, Kuberan
AU - Voges, Inga
AU - Muthurangu, Vivek
AU - Miles, Kimberley G.
AU - Greil, Gerald
AU - McMahon, Colin J.
AU - Slesnick, Timothy C.
AU - Fonseca, Brian M.
AU - Morris, Shaine A.
AU - Soslow, Jonathan H.
AU - Grosse-Wortmann, Lars
AU - Beroukhim, Rebecca S.
AU - Grotenhuis, Heynric B.
N1 - Publisher Copyright:
© 2024 The Author(s)
PY - 2024/6
Y1 - 2024/6
N2 - Cardiovascular magnetic resonance (CMR) has become the reference standard for quantitative and qualitative assessment of ventricular function, blood flow, and myocardial tissue characterization. There is a preponderance of large CMR studies and registries in adults; However, similarly powered studies are lacking for the pediatric and congenital heart disease (PCHD) population. To date, most CMR studies in children are limited to small single or multicenter studies, thereby limiting the conclusions that can be drawn. Within the PCHD CMR community, a collaborative effort has been successfully employed to recognize knowledge gaps with the aim to embolden the development and initiation of high-quality, large-scale multicenter research. In this publication, we highlight the underlying challenges and provide a practical guide toward the development of larger, multicenter initiatives focusing on PCHD populations, which can serve as a model for future multicenter efforts.
AB - Cardiovascular magnetic resonance (CMR) has become the reference standard for quantitative and qualitative assessment of ventricular function, blood flow, and myocardial tissue characterization. There is a preponderance of large CMR studies and registries in adults; However, similarly powered studies are lacking for the pediatric and congenital heart disease (PCHD) population. To date, most CMR studies in children are limited to small single or multicenter studies, thereby limiting the conclusions that can be drawn. Within the PCHD CMR community, a collaborative effort has been successfully employed to recognize knowledge gaps with the aim to embolden the development and initiation of high-quality, large-scale multicenter research. In this publication, we highlight the underlying challenges and provide a practical guide toward the development of larger, multicenter initiatives focusing on PCHD populations, which can serve as a model for future multicenter efforts.
UR - https://www.scopus.com/pages/publications/85189463377
U2 - 10.1016/j.jocmr.2024.101041
DO - 10.1016/j.jocmr.2024.101041
M3 - Review article
C2 - 38527706
AN - SCOPUS:85189463377
SN - 1097-6647
VL - 26
JO - Journal of Cardiovascular Magnetic Resonance
JF - Journal of Cardiovascular Magnetic Resonance
IS - 1
M1 - 101041
ER -