TY - JOUR
T1 - Detection of Endo-epicardial Asynchrony in the Atrial Wall Using One-Sided Unipolar and Bipolar Electrograms
AU - van der Does, Lisette J.M.E.
AU - Starreveld, Roeliene
AU - Kharbanda, Rohit K.
AU - Knops, Paul
AU - Kik, Charles
AU - Bogers, Ad J.J.C.
AU - de Groot, Natasja M.S.
N1 - Funding Information:
Prof. Dr. N.M.S. de Groot is supported by grants from the Investigator-Initiated Study Program of Biosense Webster, Inc. (IIS-331 Phase 2), CVON-AFFIP (914728), NWO-Vidi (91717339), and Medical Delta.
Publisher Copyright:
© 2021, The Author(s).
PY - 2021/10
Y1 - 2021/10
N2 - Endo-epicardial asynchrony (EEA) is a new mechanism possibly maintaining atrial fibrillation. We aimed to determine the sensitivity and best recording modus to detect EEA on electrograms recorded from one atrial side using electrogram fractionation. Simultaneously obtained right atrial endo- and epicardial electrograms from 22 patients demonstrating EEA were selected. Unipolar and (converted) bipolar electrograms were analyzed for presence and characteristics of fractionation corresponding to EEA. Sensitivity of presence of EEA corresponding fractionation was high in patients (86–96%) and moderately high (65–78%) for the asynchronous surface area for unipolar and bipolar electrograms equally. In bipolar electrograms, signal-to-noise ratio of EEA corresponding fractionation decreased and additional fractionation increased for electrograms recorded at the endocardium. Sensitivity of fractionation corresponding to EEA is high for both unipolar and bipolar electrograms. Unipolar electrograms are more suited for detection of EEA due to a larger signal-to-noise ratio and less disturbance of additional fractionation. Graphical Abstract: [Figure not available: see fulltext.].
AB - Endo-epicardial asynchrony (EEA) is a new mechanism possibly maintaining atrial fibrillation. We aimed to determine the sensitivity and best recording modus to detect EEA on electrograms recorded from one atrial side using electrogram fractionation. Simultaneously obtained right atrial endo- and epicardial electrograms from 22 patients demonstrating EEA were selected. Unipolar and (converted) bipolar electrograms were analyzed for presence and characteristics of fractionation corresponding to EEA. Sensitivity of presence of EEA corresponding fractionation was high in patients (86–96%) and moderately high (65–78%) for the asynchronous surface area for unipolar and bipolar electrograms equally. In bipolar electrograms, signal-to-noise ratio of EEA corresponding fractionation decreased and additional fractionation increased for electrograms recorded at the endocardium. Sensitivity of fractionation corresponding to EEA is high for both unipolar and bipolar electrograms. Unipolar electrograms are more suited for detection of EEA due to a larger signal-to-noise ratio and less disturbance of additional fractionation. Graphical Abstract: [Figure not available: see fulltext.].
UR - http://www.scopus.com/inward/record.url?scp=85103380157&partnerID=8YFLogxK
U2 - 10.1007/s12265-021-10111-1
DO - 10.1007/s12265-021-10111-1
M3 - Article
C2 - 33782858
AN - SCOPUS:85103380157
VL - 14
SP - 902
EP - 911
JO - Journal of Cardiovascular Translational Research
JF - Journal of Cardiovascular Translational Research
SN - 1937-5387
IS - 5
ER -