Determinants of metastatic competency in colorectal cancer

Daniele V.F. Tauriello*, Alexandre Calon, Enza Lonardo, Eduard Batlle

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

159 Citations (Scopus)
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Colorectal cancer (CRC) is one of the most common cancer types and represents a major therapeutic challenge. Although initial events in colorectal carcinogenesis are relatively well characterized and treatment for earlystage disease has significantly improved over the last decades, the mechanisms underlying metastasis - the main cause of death - remain poorly understood. Correspondingly, no effective therapy is currently available for advanced or metastatic disease. There is increasing evidence that colorectal cancer is hierarchically organized and sustained by cancer stem cells, in concert with various stromal cell types. Here, we review the interplay between cancer stem cells and their microenvironment in promoting metastasis and discuss recent insights relating to both patient prognosis and novel targeted treatment strategies. A better understanding of these topics may aid the prevention or reduction of metastatic burden.

Original languageEnglish
Pages (from-to)97-119
Number of pages23
JournalMolecular Oncology
Issue number1
Publication statusPublished - Jan 2017
Externally publishedYes

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© 2016 The Authors.


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