Determinants of renal function at hospital discharge of patients treated with renal replacement therapy in the intensive care unit

Gijs Fortrie, Susanne Stads, Hilde de Geus, Johan Groeneveld, R. Zietse, M.G.H. Betjes

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)


Purpose: Identification of risk factors for impaired renal function at hospital discharge in critically ill patients with acute kidney injury (AKI) requiring renal replacement therapy (RRT). Methods: A single-center retrospective cohort study was performed evaluating demographic and clinical parameters as potential risk factors for a modest to severely impaired renal function at hospital discharge in patients with AKI requiring RRT in the intensive care unit. Results: Of the 353 patients in our cohort, 90 (25.5%) patients had pre-existing chronic kidney disease (CKD). An estimated glomerular filtration rate (eGFR) <= 60 mL min(-1) 1.73 m(-2) at hospital discharge occurred in 64.0% of which 63.7% without known renal impairment before hospital admission and 8.2% of all cases left the hospital dialysis-dependent. Multivariable logistic regression showed that age (OR = 1.051, P < .001), serum creatinine concentration at start of RRT (OR = 1.004, P < .001 Conclusions: Elderly and patients with pre-existing CKD are at a high risk for modest to severely impaired renal function at hospital discharge after AKI requiring RRT. (C) 2013 Elsevier Inc. All rights reserved.
Original languageUndefined/Unknown
Pages (from-to)126-132
Number of pages7
JournalJournal of Critical Care
Issue number2
Publication statusPublished - 2013

Cite this