Development of a patient-specific cerebral vasculature fluid–structure-interaction model

Kevin M. Moerman*, Praneeta Konduri, Behrooz Fereidoonnezhad, Henk Marquering, Aad van der Lugt, Giulia Luraghi, Sara Bridio, Francesco Migliavacca, Jose F. Rodriguez Matas, Patrick McGarry

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Development of in-silico models of patient-specific cerebral artery networks presents several significant technical challenges: (i) The resolution and smoothness of medical CT images are much lower than the required element/cell length for FEA/CFD/FSI models; (ii) contact between vessels, and indeed self contact of high tortuosity vessel segments are not clearly identifiable from medical CT images. Commercial model construction software does not provide customised solutions for such technical challenges, with the result that accurate, efficient and automated development of patient-specific models of the cerebral vessels is not facilitated. This paper presents the development of a customised and highly automated platform for the generation of high resolution patient-specific FEA/CFD/FSI models from clinical images. This platform is used to perform the first fluid–structure-interaction patient-specific analysis of blood flow and artery deformation of an occluded cerebral vessel. Results demonstrate that in addition to flow disruption, clot occlusion significantly alters the geometry and strain distribution in the vessel network, with the blocked M2 segment undergoing axial elongation. The new computational approach presented in this study can be further developed as a clinical diagnostic tool and as a platform for thrombectomy device design.

Original languageEnglish
Article number110896
JournalJournal of Biomechanics
Volume133
Early online date3 Feb 2022
DOIs
Publication statusPublished - Mar 2022

Bibliographical note

Funding Information:
This project was funded by a European Union Horizon 2020 Research and Innovation Program , under grant agreement No. 777072 . The authors are grateful to Dr Jay Shim and Prof Gerard Ateshian (Columbia University, New York, USA) for providing advice on the FEBio FSI implementation.

Publisher Copyright:
© 2021

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