Development of human lymph nodes and Peyer's patches

Kerim Hoorweg; Tom Cupedo

doi:10.1016/j.smim.2008.02.003

Development of human lymph nodes and Peyer's patches

Kerim Hoorweg, Tom Cupedo

Hematology

Research output: Contribution to journal › Article › Academic

43 Citations (Scopus)

Abstract

In contrast to our understanding of murine lymphoid organogenesis, detailed knowledge on the mechanisms of human lymph node development is virtually lacking. This is mainly due to the obvious difficulties that accompany research using human fetal organs. In this review we will highlight current knowledge on human lymph node and Peyer's patch development and will temporally align observations made in humans with data available from murine studies. In the final paragraphs we will put this knowledge in the context of human malignancies in which interactions between lymphocytes and stroma, resembling those seen in lymphoid organs, are recapitulated. (c) 2008 Elsevier Ltd. All rights reserved.

Original language	Undefined/Unknown
Pages (from-to)	164-170
Number of pages	7
Journal	Seminars in Immunology
Volume	20
Issue number	3
DOIs	https://doi.org/10.1016/j.smim.2008.02.003
Publication status	Published - 2008

Research programs

EMC MM-02-41-04

Access to Document

10.1016/j.smim.2008.02.003

http://hdl.handle.net/1765/15926

Cite this

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title = "Development of human lymph nodes and Peyer's patches",

abstract = "In contrast to our understanding of murine lymphoid organogenesis, detailed knowledge on the mechanisms of human lymph node development is virtually lacking. This is mainly due to the obvious difficulties that accompany research using human fetal organs. In this review we will highlight current knowledge on human lymph node and Peyer's patch development and will temporally align observations made in humans with data available from murine studies. In the final paragraphs we will put this knowledge in the context of human malignancies in which interactions between lymphocytes and stroma, resembling those seen in lymphoid organs, are recapitulated. (c) 2008 Elsevier Ltd. All rights reserved.",

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AB - In contrast to our understanding of murine lymphoid organogenesis, detailed knowledge on the mechanisms of human lymph node development is virtually lacking. This is mainly due to the obvious difficulties that accompany research using human fetal organs. In this review we will highlight current knowledge on human lymph node and Peyer's patch development and will temporally align observations made in humans with data available from murine studies. In the final paragraphs we will put this knowledge in the context of human malignancies in which interactions between lymphocytes and stroma, resembling those seen in lymphoid organs, are recapitulated. (c) 2008 Elsevier Ltd. All rights reserved.

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