TY - JOUR
T1 - Diabetes and factors associated with cognitive and functional decline. The screening for CKD among older people across Europe (SCOPE) study
AU - Formiga, Francesc
AU - Badía-Tejero, Ana María
AU - Screening for CKD among Older People across Europe (SCOPE) study investigators
AU - Corsonello, Andrea
AU - Ärnlöv, Johan
AU - Carlsson, Axel
AU - Mattace-Raso, Francesco
AU - Tap, Lisanne
AU - Kostka, Tomasz
AU - Guligowska, Agnieszka
AU - Sieber, Cornel C.
AU - Kob, Robert
AU - Ben-Romano, Ronit
AU - Yehoshua, Ilan
AU - Roller-Wirnsberger, Regina
AU - Wirnsberger, Gerhard H.
AU - Fabbietti, Paolo
AU - Lattanzio, Fabrizia
AU - Moreno-González, Rafael
AU - Chivite, David
AU - Martínez, Yurema
AU - Polo, Carolina
AU - Cruzado, Josep Maria
AU - Bustacchini, Silvia
AU - Bolognini, Silvia
AU - D’Ascoli, Paola
AU - Moresi, Raffaella
AU - Di Stefano, Giuseppina
AU - Giammarchi, Cinzia
AU - Bonfigli, Anna Rita
AU - Galeazzi, Roberta
AU - Lenci, Federica
AU - Della Bella, Stefano
AU - Bordoni, Enrico
AU - Provinciali, Mauro
AU - Giacconi, Robertina
AU - Giuli, Cinzia
AU - Postacchini, Demetrio
AU - Garasto, Sabrina
AU - Cozza, Annalisa
AU - Firmani, Romano
AU - Nacciariti, Moreno
AU - Rosa, Mirko
AU - Carlsson, Axel
AU - Feldreich, Tobias
AU - Ziere, Gijsbertus
AU - Goudzwaard, Jeannette
AU - Kroc, Łukasz
AU - Sołtysik, Bartłomiej K.
AU - Pigłowska, Małgorzata
AU - Wójcik, Agnieszka
N1 - Funding Information:
The SCOPE project was granted by the European Union Horizon 2020 program, under the Grant Agreement n° 634869.
Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Nature Switzerland AG.
PY - 2023/11
Y1 - 2023/11
N2 - Background: Type 2 diabetes mellitus (DM) in older people is a heterogeneous condition that exhibits differential characteristics in comparison with younger adults. DM increases the risk of disability, is associated with dementia and loss of function, and cognition may often be interrelated and more pronounced in older patients with DM than in those without.Aims: Our aim was to evaluate the incidence of functional and/or cognitive impairment in older adults with and without DM, and its associated factors in DM participants. Methods: A 2-year prospective analysis was conducted in a European multicenter prospective cohort (SCOPE study). Older community-dwelling adults (aged ≥ 75 years) underwent a comprehensive geriatric assessment. New functional and/or cognitive decline was explored. Results: Of 1611 participants, 335 (22.0%) had DM at baseline. The percentage of participants scoring at least one ADL impairment and/or cognitive impairment (MMSE < 24) was similar in both groups (9.6%). Factors associated with any new disability in participants with DM in the multivariate analysis were female sex (OR 3.28, 95% CI 1.42–7.56), history of stroke (OR 4.58, 95% CI 1.64–12.7), and greater IADL dependency (OR 1.08 95% CI 1.02–1.15).Discussion: Association between DM and cognitive or functional decline in outpatients of 75 years and older was not found, but factors such as female gender, history of stroke, and IADL dependency could be related. Conclusion: Decline in functional and cognitive status of community-dwelling older adults with DM was similar to participants without DM in a short period of 2 years of follow-up, though several clinical factors may increase its risk in this population.
AB - Background: Type 2 diabetes mellitus (DM) in older people is a heterogeneous condition that exhibits differential characteristics in comparison with younger adults. DM increases the risk of disability, is associated with dementia and loss of function, and cognition may often be interrelated and more pronounced in older patients with DM than in those without.Aims: Our aim was to evaluate the incidence of functional and/or cognitive impairment in older adults with and without DM, and its associated factors in DM participants. Methods: A 2-year prospective analysis was conducted in a European multicenter prospective cohort (SCOPE study). Older community-dwelling adults (aged ≥ 75 years) underwent a comprehensive geriatric assessment. New functional and/or cognitive decline was explored. Results: Of 1611 participants, 335 (22.0%) had DM at baseline. The percentage of participants scoring at least one ADL impairment and/or cognitive impairment (MMSE < 24) was similar in both groups (9.6%). Factors associated with any new disability in participants with DM in the multivariate analysis were female sex (OR 3.28, 95% CI 1.42–7.56), history of stroke (OR 4.58, 95% CI 1.64–12.7), and greater IADL dependency (OR 1.08 95% CI 1.02–1.15).Discussion: Association between DM and cognitive or functional decline in outpatients of 75 years and older was not found, but factors such as female gender, history of stroke, and IADL dependency could be related. Conclusion: Decline in functional and cognitive status of community-dwelling older adults with DM was similar to participants without DM in a short period of 2 years of follow-up, though several clinical factors may increase its risk in this population.
UR - http://www.scopus.com/inward/record.url?scp=85170226361&partnerID=8YFLogxK
U2 - 10.1007/s40520-023-02536-2
DO - 10.1007/s40520-023-02536-2
M3 - Article
C2 - 37668841
AN - SCOPUS:85170226361
SN - 1594-0667
VL - 35
SP - 2693
EP - 2701
JO - Aging clinical and experimental research
JF - Aging clinical and experimental research
IS - 11
ER -
