Diabetes and factors associated with cognitive and functional decline. The screening for CKD among older people across Europe (SCOPE) study

Francesc Formiga, Ana María Badía-Tejero, SCOPE investigators, Andrea Corsonello, Johan Ärnlöv, Axel Carlsson, Francesco Mattace-Raso, Lisanne Tap, Tomasz Kostka, Agnieszka Guligowska, Cornel C. Sieber, Robert Kob, Ronit Ben-Romano, Ilan Yehoshua, Regina Roller-Wirnsberger, Gerhard H. Wirnsberger, Paolo Fabbietti*, Fabrizia Lattanzio, Rafael Moreno-González

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)



Type 2 diabetes mellitus (DM) in older people is a heterogeneous condition that exhibits differential characteristics in comparison with younger adults. DM increases the risk of disability, is associated with dementia and loss of function, and cognition may often be interrelated and more pronounced in older patients with DM than in those without.


Our aim was to evaluate the incidence of functional and/or cognitive impairment in older adults with and without DM, and its associated factors in DM participants. 


A 2-year prospective analysis was conducted in a European multicenter prospective cohort (SCOPE study). Older community-dwelling adults (aged ≥ 75 years) underwent a comprehensive geriatric assessment. New functional and/or cognitive decline was explored. 


Of 1611 participants, 335 (22.0%) had DM at baseline. The percentage of participants scoring at least one ADL impairment and/or cognitive impairment (MMSE < 24) was similar in both groups (9.6%). Factors associated with any new disability in participants with DM in the multivariate analysis were female sex (OR 3.28, 95% CI 1.42–7.56), history of stroke (OR 4.58, 95% CI 1.64–12.7), and greater IADL dependency (OR 1.08 95% CI 1.02–1.15).


Association between DM and cognitive or functional decline in outpatients of 75 years and older was not found, but factors such as female gender, history of stroke, and IADL dependency could be related. 


Decline in functional and cognitive status of community-dwelling older adults with DM was similar to participants without DM in a short period of 2 years of follow-up, though several clinical factors may increase its risk in this population.

Original languageEnglish
Pages (from-to)2693-2701
Number of pages9
JournalAging clinical and experimental research
Issue number11
Early online date5 Sept 2023
Publication statusPublished - Nov 2023

Bibliographical note

Funding Information:
The SCOPE project was granted by the European Union Horizon 2020 program, under the Grant Agreement n° 634869.

Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Nature Switzerland AG.


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