Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet

H Dohner; EH Estey; S Amadori; FR Appelbaum; T Buchner; AK Burnett; H Dombret; P Fenaux; D Grimwade; RA Larson; F Lo-Coco; T Naoe; D Niederwieser; GJ Ossenkoppele; MA Sanz; J Sierra; MS Tallman; Bob Löwenberg; CD Bloomfield

doi:10.1182/blood-2009-07-235358

Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet

H Dohner, EH Estey, S Amadori, FR Appelbaum, T Buchner, AK Burnett, H Dombret, P Fenaux, D Grimwade, RA Larson, F Lo-Coco, T Naoe, D Niederwieser, GJ Ossenkoppele, MA Sanz, J Sierra, MS Tallman, Bob Löwenberg, CD Bloomfield

Hematology

Research output: Contribution to journal › Article › Academic › peer-review

2802 Citations (Scopus)

Abstract

In 2003, an international working group last reported on recommendations for diagnosis, response assessment, and treatment outcomes in acute myeloid leukemia (AML). Since that time, considerable progress has been made in elucidating the molecular pathogenesis of the disease that has resulted in the identification of new diagnostic and prognostic markers. Furthermore, therapies are now being developed that target disease-associated molecular defects. Recent developments prompted an international expert panel to provide updated evidence- and expert opinion-based recommendations for the diagnosis and management of AML, that contain both minimal requirements for general practice as well as standards for clinical trials. A new standardized reporting system for correlation of cytogenetic and molecular genetic data with clinical data is proposed. (Blood. 2010; 115: 453-474)

Original language	Undefined/Unknown
Pages (from-to)	453-474
Number of pages	22
Journal	Blood
Volume	115
Issue number	3
DOIs	https://doi.org/10.1182/blood-2009-07-235358
Publication status	Published - 2010

Research programs

EMC MM-02-41-03

Access to Document

10.1182/blood-2009-07-235358

http://hdl.handle.net/1765/26807

Cite this

Dohner, H., Estey, EH., Amadori, S., Appelbaum, FR., Buchner, T., Burnett, AK., Dombret, H., Fenaux, P., Grimwade, D., Larson, RA., Lo-Coco, F., Naoe, T., Niederwieser, D., Ossenkoppele, GJ., Sanz, MA., Sierra, J., Tallman, MS., Löwenberg, B., & Bloomfield, CD. (2010). Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood, 115(3), 453-474. https://doi.org/10.1182/blood-2009-07-235358

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title = "Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet",

abstract = "In 2003, an international working group last reported on recommendations for diagnosis, response assessment, and treatment outcomes in acute myeloid leukemia (AML). Since that time, considerable progress has been made in elucidating the molecular pathogenesis of the disease that has resulted in the identification of new diagnostic and prognostic markers. Furthermore, therapies are now being developed that target disease-associated molecular defects. Recent developments prompted an international expert panel to provide updated evidence- and expert opinion-based recommendations for the diagnosis and management of AML, that contain both minimal requirements for general practice as well as standards for clinical trials. A new standardized reporting system for correlation of cytogenetic and molecular genetic data with clinical data is proposed. (Blood. 2010; 115: 453-474)",

author = "H Dohner and EH Estey and S Amadori and FR Appelbaum and T Buchner and AK Burnett and H Dombret and P Fenaux and D Grimwade and RA Larson and F Lo-Coco and T Naoe and D Niederwieser and GJ Ossenkoppele and MA Sanz and J Sierra and MS Tallman and Bob L{\"o}wenberg and CD Bloomfield",

year = "2010",

doi = "10.1182/blood-2009-07-235358",

language = "Undefined/Unknown",

volume = "115",

pages = "453--474",

journal = "Blood",

issn = "0006-4971",

publisher = "American Society of Hematology",

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Dohner, H, Estey, EH, Amadori, S, Appelbaum, FR, Buchner, T, Burnett, AK, Dombret, H, Fenaux, P, Grimwade, D, Larson, RA, Lo-Coco, F, Naoe, T, Niederwieser, D, Ossenkoppele, GJ, Sanz, MA, Sierra, J, Tallman, MS, Löwenberg, B & Bloomfield, CD 2010, 'Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet', Blood, vol. 115, no. 3, pp. 453-474. https://doi.org/10.1182/blood-2009-07-235358

TY - JOUR

T1 - Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet

AU - Dohner, H

AU - Estey, EH

AU - Amadori, S

AU - Appelbaum, FR

AU - Buchner, T

AU - Burnett, AK

AU - Dombret, H

AU - Fenaux, P

AU - Grimwade, D

AU - Larson, RA

AU - Lo-Coco, F

AU - Naoe, T

AU - Niederwieser, D

AU - Ossenkoppele, GJ

AU - Sanz, MA

AU - Sierra, J

AU - Tallman, MS

AU - Löwenberg, Bob

AU - Bloomfield, CD

PY - 2010

Y1 - 2010

N2 - In 2003, an international working group last reported on recommendations for diagnosis, response assessment, and treatment outcomes in acute myeloid leukemia (AML). Since that time, considerable progress has been made in elucidating the molecular pathogenesis of the disease that has resulted in the identification of new diagnostic and prognostic markers. Furthermore, therapies are now being developed that target disease-associated molecular defects. Recent developments prompted an international expert panel to provide updated evidence- and expert opinion-based recommendations for the diagnosis and management of AML, that contain both minimal requirements for general practice as well as standards for clinical trials. A new standardized reporting system for correlation of cytogenetic and molecular genetic data with clinical data is proposed. (Blood. 2010; 115: 453-474)

AB - In 2003, an international working group last reported on recommendations for diagnosis, response assessment, and treatment outcomes in acute myeloid leukemia (AML). Since that time, considerable progress has been made in elucidating the molecular pathogenesis of the disease that has resulted in the identification of new diagnostic and prognostic markers. Furthermore, therapies are now being developed that target disease-associated molecular defects. Recent developments prompted an international expert panel to provide updated evidence- and expert opinion-based recommendations for the diagnosis and management of AML, that contain both minimal requirements for general practice as well as standards for clinical trials. A new standardized reporting system for correlation of cytogenetic and molecular genetic data with clinical data is proposed. (Blood. 2010; 115: 453-474)

U2 - 10.1182/blood-2009-07-235358

DO - 10.1182/blood-2009-07-235358

M3 - Article

SN - 0006-4971

VL - 115

SP - 453

EP - 474

JO - Blood

JF - Blood

IS - 3

ER -