Diagnosis of urinary schistosomiasis: A novel approach to compare bladder pathology measured by ultrasound and three methods for hematuria detection

Marieke J. Van Der Werf*, Sake J. De Vlas

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

27 Citations (Scopus)

Abstract

We aggregated published data from field studies documenting prevalence of Schistosoma haematobium infection and bladder pathology determined by ultrasonography or hematuria detected by reagent strip, questionnaire, or visual examination. A mathematical expression was used to describe the associations between prevalence of pathology/morbidity and infection. This allows for indirect comparison of these methods, which are rarely used simultaneously. All four methods showed a similar, marked association with infection. Surprisingly, ultrasound revealed higher prevalences of pathology in schools than in communities with the same prevalence of infection, implying a need for age-related cut-off values. Reagent strip testing yielded a higher prevalence than questionnaire, which in turn was higher than by visual examination. After correction for morbidity due to other causes, a consistent ratio in prevalence of hematuria of 3:2:1 resulted for the three respective methods. The simple questionnaire approach is not markedly inferior to the other techniques, making it the best option for field use.

Original languageEnglish
Pages (from-to)98-106
Number of pages9
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume71
Issue number1
DOIs
Publication statusPublished - Jul 2004

Fingerprint

Dive into the research topics of 'Diagnosis of urinary schistosomiasis: A novel approach to compare bladder pathology measured by ultrasound and three methods for hematuria detection'. Together they form a unique fingerprint.

Cite this