Diagnosis-related deterioration of lung function after extracorporeal membrane oxygenation

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The aim of the study was to assess lung function longitudinally after neonatal extracorporeal membrane oxygenation (ECMO), and to identify any effects of diagnosis and perinatal characteristics. 121 neonatal ECMO-treated children (70 with meconium aspiration syndrome, 20 congenital diaphragmatic hernia and 31 with other diagnoses) performed a total of 191 lung function measurements at 5, 8 and/or 12 yrs. We assessed dynamic and static lung volumes, reversibility of airway obstruction and diffusion capacity. Mean SDS forced expiratory volume in 1 s (FEV1) at 5 yrs before and after bronchodilation (-0.51 and 0.07) was significantly higher than at 8 (-0.79 and -0.4; p<0.04) and 12 yrs (-1.10 and -0.52; p<0.003). Mean SDS for all spirometric parameters before and after bronchodilation were significantly lower in the congenital diaphragmatic hernia group compared with the other diagnostic groups (all p <= 0.025). A significant volume of trapped air was observed in 86% patients with congenital diaphragma Long-term pulmonary sequelae after neonatal ECMO-treatment mainly occur in congenital diaphragmatic hernia patients and tend to deteriorate over time.
Original languageUndefined/Unknown
Pages (from-to)1531-1537
Number of pages7
JournalEuropean Respiratory Journal
Issue number6
Publication statusPublished - 2012

Research programs

  • EMC MGC-02-53-01-A
  • EMC NIHES-01-66-01
  • EMC OR-01-54-02

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