Diagnostic accuracy of 320-row multidetector computed tomography coronary angiography in the non-invasive evaluation of significant coronary artery disease

FR de Graaf, JD Schuijf, JE Velzen, LJ Kroft, A de Roos, JHC (Johan) Reiber, Eric Boersma, MJ Schalij, F Spano, JW Jukema, EE van der Wall, JJ Bax

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Abstract

Multidetector computed tomography coronary angiography (CTA) has emerged as a feasible imaging modality for non-invasive assessment of coronary artery disease (CAD). Recently, 320-row CTA systems were introduced, with 16 cm anatomical coverage, allowing image acquisition of the entire heart within a single heart beat. The aim of the present study was to assess the diagnostic accuracy of 320-row CTA in patients with known or suspected CAD. A total of 64 patients (34 male, mean age 61 +/- 16 years) underwent CTA and invasive coronary angiography. All CTA scans were evaluated for the presence of obstructive coronary stenosis by a blinded expert, and results were compared with quantitative coronary angiography. Four patients were excluded from initial analysis due to non-diagnostic image quality. Sensitivity, specificity, and positive and negative predictive values to detect >= 50% luminal narrowing on a patient basis were 100, 88, 92, and 100%, respectively. Moreover, sensitivity, specificity, and positive and negative predictive values to detect >= 70% luminal narrowing on a patient basis were 94, 95, 88, and 98%, respectively. With inclusion of non-diagnostic imaging studies, sensitivity, specificity, and positive and negative predictive values to detect >= 50% luminal narrowing on a patient basis were 100, 81, 88, and 100%, respectively. The current study shows that 320-row CTA allows accurate non-invasive assessment of significant CAD.
Original languageUndefined/Unknown
Pages (from-to)1908-1915
Number of pages8
JournalEuropean Heart Journal
Volume31
Issue number15
DOIs
Publication statusPublished - 2010

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