TY - JOUR
T1 - Diagnostic accuracy of 320-row multidetector computed tomography coronary angiography in the non-invasive evaluation of significant coronary artery disease
AU - de Graaf, FR
AU - Schuijf, JD
AU - Velzen, JE
AU - Kroft, LJ
AU - de Roos, A
AU - Reiber, JHC (Johan)
AU - Boersma, Eric
AU - Schalij, MJ
AU - Spano, F
AU - Jukema, JW
AU - van der Wall, EE
AU - Bax, JJ
PY - 2010
Y1 - 2010
N2 - Multidetector computed tomography coronary angiography (CTA) has emerged as a feasible imaging modality for non-invasive assessment of coronary artery disease (CAD). Recently, 320-row CTA systems were introduced, with 16 cm anatomical coverage, allowing image acquisition of the entire heart within a single heart beat. The aim of the present study was to assess the diagnostic accuracy of 320-row CTA in patients with known or suspected CAD. A total of 64 patients (34 male, mean age 61 +/- 16 years) underwent CTA and invasive coronary angiography. All CTA scans were evaluated for the presence of obstructive coronary stenosis by a blinded expert, and results were compared with quantitative coronary angiography. Four patients were excluded from initial analysis due to non-diagnostic image quality. Sensitivity, specificity, and positive and negative predictive values to detect >= 50% luminal narrowing on a patient basis were 100, 88, 92, and 100%, respectively. Moreover, sensitivity, specificity, and positive and negative predictive values to detect >= 70% luminal narrowing on a patient basis were 94, 95, 88, and 98%, respectively. With inclusion of non-diagnostic imaging studies, sensitivity, specificity, and positive and negative predictive values to detect >= 50% luminal narrowing on a patient basis were 100, 81, 88, and 100%, respectively. The current study shows that 320-row CTA allows accurate non-invasive assessment of significant CAD.
AB - Multidetector computed tomography coronary angiography (CTA) has emerged as a feasible imaging modality for non-invasive assessment of coronary artery disease (CAD). Recently, 320-row CTA systems were introduced, with 16 cm anatomical coverage, allowing image acquisition of the entire heart within a single heart beat. The aim of the present study was to assess the diagnostic accuracy of 320-row CTA in patients with known or suspected CAD. A total of 64 patients (34 male, mean age 61 +/- 16 years) underwent CTA and invasive coronary angiography. All CTA scans were evaluated for the presence of obstructive coronary stenosis by a blinded expert, and results were compared with quantitative coronary angiography. Four patients were excluded from initial analysis due to non-diagnostic image quality. Sensitivity, specificity, and positive and negative predictive values to detect >= 50% luminal narrowing on a patient basis were 100, 88, 92, and 100%, respectively. Moreover, sensitivity, specificity, and positive and negative predictive values to detect >= 70% luminal narrowing on a patient basis were 94, 95, 88, and 98%, respectively. With inclusion of non-diagnostic imaging studies, sensitivity, specificity, and positive and negative predictive values to detect >= 50% luminal narrowing on a patient basis were 100, 81, 88, and 100%, respectively. The current study shows that 320-row CTA allows accurate non-invasive assessment of significant CAD.
U2 - 10.1093/eurheartj/ehp571
DO - 10.1093/eurheartj/ehp571
M3 - Article
C2 - 20047991
SN - 0195-668X
VL - 31
SP - 1908
EP - 1915
JO - European Heart Journal
JF - European Heart Journal
IS - 15
ER -