Diagnostic accuracy of angiography-based vessel fractional flow reserve after chronic coronary total occlusion recanalization

Alessandra Scoccia; Paola Scarparo; Tara Neleman; Hala Kakar; Jeroen Wilschut; Wijnand K. Den Dekker; Felix Zijlstra; Nicolas M. Van Mieghem; Joost Daemen; Roberto Diletti

doi:10.1002/ccd.30439

Diagnostic accuracy of angiography-based vessel fractional flow reserve after chronic coronary total occlusion recanalization

Alessandra Scoccia, Paola Scarparo, Tara Neleman, Hala Kakar, Jeroen Wilschut, Wijnand K. Den Dekker, Felix Zijlstra, Nicolas M. Van Mieghem, Joost Daemen, Roberto Diletti^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background: Angiography-based vessel fractional flow reserve (vFFR) demonstrated a strong correlation with invasive fractional flow reserve (FFR) in both a pre- and post-percutaneous coronary intervention (PCI) setting. However, the role of vFFR and its correlation with post-PCI FFR in chronic coronary occlusions (CTO) has not been evaluated yet. We sought to investigate the diagnostic performance of post-PCI vFFR with post-PCI FFR as a reference in patients undergoing successful CTO PCI. Methods: Between March 2016 and April 2020, a total of 80 patients from the FFR-SEARCH (prospective registry) and FFR REACT (randomized controlled trial) studies underwent successful CTO recanalization with post-PCI FFR measurements. Results: A total of 50 patients (median age 66 (interquartile range [IQR]: 56−74) years, 76% were male) were eligible for the analysis. Median post-PCI FFR was 0.89 (IQR: 0.84−0.94), while median post-PCI vFFR was 0.91 (IQR: 0.85−0.94) (p 0.10). Suboptimal physiological results, defined as FFR and vFFR <0.90, were identified in 26 (52%) and in 21 (42%) patients, respectively. A strong correlation (r = 0.82) was found between vFFR and FFR with a mean bias of 0.013 ± 0.051. Receiver-operating characteristics curve analysis revealed an excellent accuracy of vFFR in predicting FFR <0.90 (area under the curve: 0.97; 95% confidence interval: 0.93−1.00). Conclusion: Post-PCI vFFR shows a good correlation with post-PCI FFR and a high diagnostic accuracy for post-PCI FFR ≤0.90 in patients undergoing successful PCI of a CTO lesion.

Original language	English
Pages (from-to)	964-970
Number of pages	7
Journal	Catheterization and Cardiovascular Interventions
Volume	100
Issue number	6
Early online date	2 Nov 2022
DOIs	https://doi.org/10.1002/ccd.30439
Publication status	Published - 15 Nov 2022

Bibliographical note

Funding Information:
Dr Diletti has received institutional research grant support from ACIST Medical Systems, Inc. Joost Daemen received institutional research support from Astra Zeneca, Abbott Vascular, Boston Scientific, Acist Medical, Medtronic, Pie Medical, ReCor medical and Pulse Cath. Nicolas M. Van Mieghem received research grant support from Edwards, Medtronic, Abbott, Boston Scientific, Pulse Cath, Acist Medical, and Essential Medical. Tara Neleman received institutional research grant support from Acist Medical. The remaining authors declare no conflict of interest.

Publisher Copyright:
© 2022 The Authors. Catheterization and Cardiovascular Interventions published by Wiley Periodicals LLC.

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Diagnostic accuracy of angiography-based vessel fractional flow reserve after chronic coronary total occlusion recanalizationFinal published version, 815 KBLicence: CC BY-NC-ND

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Scoccia, A., Scarparo, P., Neleman, T., Kakar, H., Wilschut, J., Den Dekker, W. K., Zijlstra, F., Van Mieghem, N. M., Daemen, J., & Diletti, R. (2022). Diagnostic accuracy of angiography-based vessel fractional flow reserve after chronic coronary total occlusion recanalization. Catheterization and Cardiovascular Interventions, 100(6), 964-970. https://doi.org/10.1002/ccd.30439

@article{9b543a7b660a48b18add6b29fc483327,

title = "Diagnostic accuracy of angiography-based vessel fractional flow reserve after chronic coronary total occlusion recanalization",

abstract = "Background: Angiography-based vessel fractional flow reserve (vFFR) demonstrated a strong correlation with invasive fractional flow reserve (FFR) in both a pre- and post-percutaneous coronary intervention (PCI) setting. However, the role of vFFR and its correlation with post-PCI FFR in chronic coronary occlusions (CTO) has not been evaluated yet. We sought to investigate the diagnostic performance of post-PCI vFFR with post-PCI FFR as a reference in patients undergoing successful CTO PCI. Methods: Between March 2016 and April 2020, a total of 80 patients from the FFR-SEARCH (prospective registry) and FFR REACT (randomized controlled trial) studies underwent successful CTO recanalization with post-PCI FFR measurements. Results: A total of 50 patients (median age 66 (interquartile range [IQR]: 56−74) years, 76% were male) were eligible for the analysis. Median post-PCI FFR was 0.89 (IQR: 0.84−0.94), while median post-PCI vFFR was 0.91 (IQR: 0.85−0.94) (p 0.10). Suboptimal physiological results, defined as FFR and vFFR <0.90, were identified in 26 (52%) and in 21 (42%) patients, respectively. A strong correlation (r = 0.82) was found between vFFR and FFR with a mean bias of 0.013 ± 0.051. Receiver-operating characteristics curve analysis revealed an excellent accuracy of vFFR in predicting FFR <0.90 (area under the curve: 0.97; 95% confidence interval: 0.93−1.00). Conclusion: Post-PCI vFFR shows a good correlation with post-PCI FFR and a high diagnostic accuracy for post-PCI FFR ≤0.90 in patients undergoing successful PCI of a CTO lesion.",

author = "Alessandra Scoccia and Paola Scarparo and Tara Neleman and Hala Kakar and Jeroen Wilschut and {Den Dekker}, {Wijnand K.} and Felix Zijlstra and {Van Mieghem}, {Nicolas M.} and Joost Daemen and Roberto Diletti",

note = "Funding Information: Dr Diletti has received institutional research grant support from ACIST Medical Systems, Inc. Joost Daemen received institutional research support from Astra Zeneca, Abbott Vascular, Boston Scientific, Acist Medical, Medtronic, Pie Medical, ReCor medical and Pulse Cath. Nicolas M. Van Mieghem received research grant support from Edwards, Medtronic, Abbott, Boston Scientific, Pulse Cath, Acist Medical, and Essential Medical. Tara Neleman received institutional research grant support from Acist Medical. The remaining authors declare no conflict of interest. Publisher Copyright: {\textcopyright} 2022 The Authors. Catheterization and Cardiovascular Interventions published by Wiley Periodicals LLC.",

year = "2022",

month = nov,

day = "15",

doi = "10.1002/ccd.30439",

language = "English",

volume = "100",

pages = "964--970",

journal = "Catheterization and Cardiovascular Interventions",

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}

Scoccia, A , Scarparo, P , Neleman, T , Kakar, H, Wilschut, J, Den Dekker, WK , Zijlstra, F , Van Mieghem, NM , Daemen, J & Diletti, R 2022, 'Diagnostic accuracy of angiography-based vessel fractional flow reserve after chronic coronary total occlusion recanalization', Catheterization and Cardiovascular Interventions, vol. 100, no. 6, pp. 964-970. https://doi.org/10.1002/ccd.30439

TY - JOUR

T1 - Diagnostic accuracy of angiography-based vessel fractional flow reserve after chronic coronary total occlusion recanalization

AU - Scoccia, Alessandra

AU - Scarparo, Paola

AU - Neleman, Tara

AU - Kakar, Hala

AU - Wilschut, Jeroen

AU - Den Dekker, Wijnand K.

AU - Zijlstra, Felix

AU - Van Mieghem, Nicolas M.

AU - Daemen, Joost

AU - Diletti, Roberto

N1 - Funding Information: Dr Diletti has received institutional research grant support from ACIST Medical Systems, Inc. Joost Daemen received institutional research support from Astra Zeneca, Abbott Vascular, Boston Scientific, Acist Medical, Medtronic, Pie Medical, ReCor medical and Pulse Cath. Nicolas M. Van Mieghem received research grant support from Edwards, Medtronic, Abbott, Boston Scientific, Pulse Cath, Acist Medical, and Essential Medical. Tara Neleman received institutional research grant support from Acist Medical. The remaining authors declare no conflict of interest. Publisher Copyright: © 2022 The Authors. Catheterization and Cardiovascular Interventions published by Wiley Periodicals LLC.

PY - 2022/11/15

Y1 - 2022/11/15

N2 - Background: Angiography-based vessel fractional flow reserve (vFFR) demonstrated a strong correlation with invasive fractional flow reserve (FFR) in both a pre- and post-percutaneous coronary intervention (PCI) setting. However, the role of vFFR and its correlation with post-PCI FFR in chronic coronary occlusions (CTO) has not been evaluated yet. We sought to investigate the diagnostic performance of post-PCI vFFR with post-PCI FFR as a reference in patients undergoing successful CTO PCI. Methods: Between March 2016 and April 2020, a total of 80 patients from the FFR-SEARCH (prospective registry) and FFR REACT (randomized controlled trial) studies underwent successful CTO recanalization with post-PCI FFR measurements. Results: A total of 50 patients (median age 66 (interquartile range [IQR]: 56−74) years, 76% were male) were eligible for the analysis. Median post-PCI FFR was 0.89 (IQR: 0.84−0.94), while median post-PCI vFFR was 0.91 (IQR: 0.85−0.94) (p 0.10). Suboptimal physiological results, defined as FFR and vFFR <0.90, were identified in 26 (52%) and in 21 (42%) patients, respectively. A strong correlation (r = 0.82) was found between vFFR and FFR with a mean bias of 0.013 ± 0.051. Receiver-operating characteristics curve analysis revealed an excellent accuracy of vFFR in predicting FFR <0.90 (area under the curve: 0.97; 95% confidence interval: 0.93−1.00). Conclusion: Post-PCI vFFR shows a good correlation with post-PCI FFR and a high diagnostic accuracy for post-PCI FFR ≤0.90 in patients undergoing successful PCI of a CTO lesion.

AB - Background: Angiography-based vessel fractional flow reserve (vFFR) demonstrated a strong correlation with invasive fractional flow reserve (FFR) in both a pre- and post-percutaneous coronary intervention (PCI) setting. However, the role of vFFR and its correlation with post-PCI FFR in chronic coronary occlusions (CTO) has not been evaluated yet. We sought to investigate the diagnostic performance of post-PCI vFFR with post-PCI FFR as a reference in patients undergoing successful CTO PCI. Methods: Between March 2016 and April 2020, a total of 80 patients from the FFR-SEARCH (prospective registry) and FFR REACT (randomized controlled trial) studies underwent successful CTO recanalization with post-PCI FFR measurements. Results: A total of 50 patients (median age 66 (interquartile range [IQR]: 56−74) years, 76% were male) were eligible for the analysis. Median post-PCI FFR was 0.89 (IQR: 0.84−0.94), while median post-PCI vFFR was 0.91 (IQR: 0.85−0.94) (p 0.10). Suboptimal physiological results, defined as FFR and vFFR <0.90, were identified in 26 (52%) and in 21 (42%) patients, respectively. A strong correlation (r = 0.82) was found between vFFR and FFR with a mean bias of 0.013 ± 0.051. Receiver-operating characteristics curve analysis revealed an excellent accuracy of vFFR in predicting FFR <0.90 (area under the curve: 0.97; 95% confidence interval: 0.93−1.00). Conclusion: Post-PCI vFFR shows a good correlation with post-PCI FFR and a high diagnostic accuracy for post-PCI FFR ≤0.90 in patients undergoing successful PCI of a CTO lesion.

UR - http://www.scopus.com/inward/record.url?scp=85141435101&partnerID=8YFLogxK

U2 - 10.1002/ccd.30439

DO - 10.1002/ccd.30439

M3 - Article

C2 - 36321612

AN - SCOPUS:85141435101

SN - 1522-1946

VL - 100

SP - 964

EP - 970

JO - Catheterization and Cardiovascular Interventions

JF - Catheterization and Cardiovascular Interventions

IS - 6

ER -

Diagnostic accuracy of angiography-based vessel fractional flow reserve after chronic coronary total occlusion recanalization

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