Diagnostic accuracy of consensus diagnostic criteria for frontotemporal dementia in a memory clinic population

YAL Pijnenburg, JL Mulder, J.C. van Swieten, BMJ Uitdehaag, M (Martijn) Stevens, P Scheltens, C (Cees) Jonker

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Abstract

Background/Aims: The goal of the present study was to evaluate the diagnostic accuracy of the core diagnostic criteria for frontotemporal dementia (FTD) [Neary D, et al: Neurology 1998; 51: 1546-1554] within a memory clinic population. Methods: The 5 core diagnostic criteria for FTD were operationalised in an informant-based written questionnaire. For a diagnosis of FTD the total clinical picture was weighted with findings on additional investigations and possible exclusion criteria, with follow-up of at least 1 year. Results: The operationalised core criteria for FTD had a sensitivity of 79% (95% CI = 57-92) and a specificity of 90% (95% CI = 85-94). Conclusion: The core diagnostic criteria for FTD applied in a caregiver questionnaire have good diagnostic accuracy among subjects without advanced dementia attending a memory clinic. This stresses the importance of the informant-based history in the differential diagnosis of dementia. Copyright (C) 2008 S. Karger AG, Basel.
Original languageUndefined/Unknown
Pages (from-to)157-164
Number of pages8
JournalDementia and Geriatric Cognitive Disorders
Volume25
Issue number2
DOIs
Publication statusPublished - 2008

Research programs

  • EMC MM-04-44-02

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