Diagnostic Work-up of Acute Coronary Syndrome: The interplay between high-sensitivity troponins and coronary CT angiography

Research output: Types of ThesisDoctoral ThesisInternal

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Abstract

In this thesis the interplay between high-sensitivity cardiac troponin T and coronary computed tomography angiography (CCTA) in the assessment of patients presenting with acute chest pain to the emergency department (ED) is evaluated. In Part I we discuss the new role of non-invasive imaging, such as CCTA, as a gatekeeper for invasive coronary angiography in the era of high-sensitivity cardiac troponin assays and give an overview of the use of CCTA in suspected non-ST-segment elevation acute coronary syndrome (NSTE-ACS) patients. In Part II we investigate various risk stratification strategies and sex-associated differences in a low-risk suspected NSTE-ACS population. Finally, in Part III of the thesis we focus on the clinical value of new accelerated diagnostic protocols with high-sensitivity cardiac troponin assays for suspected NSTE-ACS patients and the role of CCTA in those with non-conclusive work-up.
Original languageEnglish
Awarding Institution
  • Erasmus University Rotterdam
Supervisors/Advisors
  • Zijlstra, Felix, Supervisor
  • Budde, Ricardo, Supervisor
  • Dubois, Eric, Co-supervisor
  • Dedic, Admir, Co-supervisor
Award date9 Oct 2023
Place of PublicationRotterdam
Print ISBNs978-94-6469-024-8
Publication statusPublished - 9 Nov 2022

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