TY - JOUR
T1 - Dichotomal effect of the coumadin derivative warfarin on inflammatory signal transduction
AU - Kater, Arnon P.
AU - Peppelenbosch, Maikel P.
AU - Brandjes, Dees P.M.
AU - Lumbantobing, Mika
PY - 2002/11
Y1 - 2002/11
N2 - Warfarin, a widely prescribed drug for preventing thrombosis, is thought to act solely through inhibition of vitamin K-dependent coagulation factors. Low concentrations of warfarin inhibit interleukin-6 production and phosphorylation of I-κB but not activation of p38 mitogen-activated protein kinase. Thus, warfarin inhibits inflammatory signal transduction, and this may contribute to clinical effects of warfarin.
AB - Warfarin, a widely prescribed drug for preventing thrombosis, is thought to act solely through inhibition of vitamin K-dependent coagulation factors. Low concentrations of warfarin inhibit interleukin-6 production and phosphorylation of I-κB but not activation of p38 mitogen-activated protein kinase. Thus, warfarin inhibits inflammatory signal transduction, and this may contribute to clinical effects of warfarin.
UR - http://www.scopus.com/inward/record.url?scp=0036844483&partnerID=8YFLogxK
U2 - 10.1128/CDLI.9.6.1396-1397.2002
DO - 10.1128/CDLI.9.6.1396-1397.2002
M3 - Article
C2 - 12414784
AN - SCOPUS:0036844483
SN - 1071-412X
VL - 9
SP - 1396
EP - 1397
JO - Clinical and Diagnostic Laboratory Immunology
JF - Clinical and Diagnostic Laboratory Immunology
IS - 6
ER -