Dietary factors and onset of natural menopause: A systematic review and meta-analysis

Giorgia Grisotto, Julian S. Farago, Petek E. Taneri, Faina Wehrli, Zayne M. Roa-Díaz, Beatrice Minder, Marija Glisic, Valentina Gonzalez-Jaramillo, Trudy Voortman, Pedro Marques-Vidal, Oscar H. Franco, Taulant Muka*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

3 Citations (Scopus)
29 Downloads (Pure)

Abstract

Background: Diet has been suggested to play a role in determining the age at natural menopause; however, the evidence is inconsistent. Objective: We systematically reviewed and evaluated published research about associations between diet and onset of natural menopause (ONM). Methods: We searched 6 databases (Medline, Embase, Cochrane, PubMed, Web of Science and Google Scholar) through January 21,2021 to identify prospective studies assessing the association between diet and ONM. Two independent reviewers extracted data using a predesigned data-collection form. Pooled hazard risks (HRs) were calculated using random effect models. Results: Of the 6,137 eligible references we reviewed, we included 15 articles in our final analysis. Those 15 articles included 91,554 women out of 298,413 who experienced natural menopause during follow-up. Overall, there were 89 food groups investigated, 38 macronutrients and micronutrients, and 6 dietary patterns. Among the food groups, higher intake of green and yellow vegetables was associated with earlier age of ONM, while high intakes of some dairy products, such as low-fat, skimmed milk, and low intake of alcohol were associated with a later onset. We observed no consistent association between macronutrient and micronutrient intake and ONM. Our results suggests that a vegetarian diet could be associated with early ONM; we did not observe any other consistent effect from other dietary patterns. Limitations included the number of studies, lack of replication studies and the research being of an observational nature; most studies (11/15) were at medium risk of bias. Conclusion: Although some food items were associated with ONM, the overall evidence about associations between diet and ONM remains controversial. Prospero id: CRD42021232087

Original languageEnglish
Pages (from-to)15-32
Number of pages18
JournalMaturitas
Volume159
Early online date22 Dec 2021
DOIs
Publication statusPublished - May 2022

Bibliographical note

Funding Information:
GG has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No 801076 through the SSPH+ Global Ph.D. Fellowship Program in Public Health Sciences (GlobalP3HS) of the Swiss School of Public Health. The funding agency has no role in the study (conceptualization, design, data collection, analysis and writing).

Funding Information:
GG has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No 801076 through the SSPH+ Global Ph.D. Fellowship Program in Public Health Sciences (GlobalP3HS) of the Swiss School of Public Health. The funding agency has no role in the study (conceptualization, design, data collection, analysis and writing) .

Publisher Copyright:
© 2021

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