TY - JOUR
T1 - Difference in time to positivity of hub-blood versus nonhub-blood cultures is not useful for the diagnosis of catheter-related bloodstream infection in critically ill patients
AU - Rijnders, Bart J.A.
AU - Verwaest, Charles
AU - Peetermans, Willy E.
AU - Wilmer, Alexander
AU - Vandecasteele, Stefaan
AU - Van Eldere, Johan
AU - Van Wijngaerden, Eric
PY - 2001
Y1 - 2001
N2 - Objective: The differential time to positivity (DTTP), defined as the difference in time necessary for the blood cultures taken by a peripheral puncture and through the catheter to become positive has been suggested to be useful in differentiating between catheter-related bloodstream infection (CR-BSI) and other sources of bacteremia. A DTTP of >120 mins was found predominantly in CR-BSI. The objective of our study was to investigate whether DTTP is useful for the diagnosis of CR-BSI in a medical-surgical intensive care unit. Design: Prospective clinical study. Setting: A 60-bed medical-surgical intensive care unit of a university hospital. Patients: One hundred consecutive adult patients from whom catheter(s) were to be removed for suspected CR-BSI were studied. Intervention: A blood culture (using aerobic and anaerobic culture bottles) was first taken from a new puncture site. Next, a blood culture was taken through every intravascular catheter in place. Measurements and Results: DTTP was calculated using the automated BacT/Alert blood culture system. Three patients had CR-BSI and nine patients had noncatheter-related bacteremia. Five patients had catheter-related sepsis without proven bacteremia. There was no significant difference in median DTTP between patients with CR-BSI and noncatheter-related bacteremia (2.1 hrs and 3.3 hrs, respectively; p = .6). Moreover, catheter-related sepsis in patients without bacteremia could not be detected using DTTP. Conclusion: DTTP seems not to be useful for the diagnosis of CR-BSI in a medical-surgical intensive care unit.
AB - Objective: The differential time to positivity (DTTP), defined as the difference in time necessary for the blood cultures taken by a peripheral puncture and through the catheter to become positive has been suggested to be useful in differentiating between catheter-related bloodstream infection (CR-BSI) and other sources of bacteremia. A DTTP of >120 mins was found predominantly in CR-BSI. The objective of our study was to investigate whether DTTP is useful for the diagnosis of CR-BSI in a medical-surgical intensive care unit. Design: Prospective clinical study. Setting: A 60-bed medical-surgical intensive care unit of a university hospital. Patients: One hundred consecutive adult patients from whom catheter(s) were to be removed for suspected CR-BSI were studied. Intervention: A blood culture (using aerobic and anaerobic culture bottles) was first taken from a new puncture site. Next, a blood culture was taken through every intravascular catheter in place. Measurements and Results: DTTP was calculated using the automated BacT/Alert blood culture system. Three patients had CR-BSI and nine patients had noncatheter-related bacteremia. Five patients had catheter-related sepsis without proven bacteremia. There was no significant difference in median DTTP between patients with CR-BSI and noncatheter-related bacteremia (2.1 hrs and 3.3 hrs, respectively; p = .6). Moreover, catheter-related sepsis in patients without bacteremia could not be detected using DTTP. Conclusion: DTTP seems not to be useful for the diagnosis of CR-BSI in a medical-surgical intensive care unit.
UR - http://www.scopus.com/inward/record.url?scp=0034960391&partnerID=8YFLogxK
U2 - 10.1097/00003246-200107000-00016
DO - 10.1097/00003246-200107000-00016
M3 - Article
C2 - 11445695
AN - SCOPUS:0034960391
SN - 0090-3493
VL - 29
SP - 1399
EP - 1403
JO - Critical Care Medicine
JF - Critical Care Medicine
IS - 7
ER -