DiffErenCes in AntihypertenSive Drug Blood Levels in Patients with HypertensiON (DECISION): Protocol for a Prospective Observational Study Comparing Pharmacokinetics and Pharmacodynamics Between Young and Elderly Patients

Dimokrat Hassan; Laura E.J. Peeters; Birgit C.P. Koch; Jorie Versmissen

doi:10.1007/s40292-022-00505-w

DiffErenCes in AntihypertenSive Drug Blood Levels in Patients with HypertensiON (DECISION): Protocol for a Prospective Observational Study Comparing Pharmacokinetics and Pharmacodynamics Between Young and Elderly Patients

Dimokrat Hassan^*
, Laura E.J. Peeters
, Birgit C.P. Koch
, Jorie Versmissen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

5 Citations (Scopus)

47 Downloads (Pure)

Abstract

Adequate controlled blood pressure decreases the risk of cardiovascular events. However, the elderly are more vulnerable and thereby more prone to side effects of antihypertensive drugs. A lack of pharmacokinetic and pharmacodynamic (PK/PD) studies in older patients makes specific and tailored advices towards antihypertensive drug therapy difficult. The aim of our study, DiffErenCes In antihypertenSive drug levels In patients with hypertensiON (DECISION), is to fill in this PK/PD knowledge gap and move towards precision dosing. DECISION is a prospective observational PK/PD study set up to determine the difference in exposure to the antihypertensive drugs, losartan and perindopril, measured by drug levels in blood. The area under the curve (AUC; PK) and furthermore the association between the AUC and the effect on blood pressure (PD) will be compared between elderly and younger patients.

Original language	English
Pages (from-to)	239-243
Number of pages	5
Journal	High Blood Pressure and Cardiovascular Prevention
Volume	29
Issue number	3
DOIs	https://doi.org/10.1007/s40292-022-00505-w
Publication status	Published - May 2022

Bibliographical note

Funding Information:
The DECISION study is supported by the Erasmus MC grant mRace with project number 2020-20207.

Publisher Copyright:
© 2022, The Author(s).

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Hassan, D., Peeters, L. E. J., Koch, B. C. P., & Versmissen, J. (2022). DiffErenCes in AntihypertenSive Drug Blood Levels in Patients with HypertensiON (DECISION): Protocol for a Prospective Observational Study Comparing Pharmacokinetics and Pharmacodynamics Between Young and Elderly Patients. High Blood Pressure and Cardiovascular Prevention, 29(3), 239-243. https://doi.org/10.1007/s40292-022-00505-w

Hassan, Dimokrat ; Peeters, Laura E.J. ; Koch, Birgit C.P. et al. / DiffErenCes in AntihypertenSive Drug Blood Levels in Patients with HypertensiON (DECISION) : Protocol for a Prospective Observational Study Comparing Pharmacokinetics and Pharmacodynamics Between Young and Elderly Patients. In: High Blood Pressure and Cardiovascular Prevention. 2022 ; Vol. 29, No. 3. pp. 239-243.

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title = "DiffErenCes in AntihypertenSive Drug Blood Levels in Patients with HypertensiON (DECISION): Protocol for a Prospective Observational Study Comparing Pharmacokinetics and Pharmacodynamics Between Young and Elderly Patients",

abstract = "Adequate controlled blood pressure decreases the risk of cardiovascular events. However, the elderly are more vulnerable and thereby more prone to side effects of antihypertensive drugs. A lack of pharmacokinetic and pharmacodynamic (PK/PD) studies in older patients makes specific and tailored advices towards antihypertensive drug therapy difficult. The aim of our study, DiffErenCes In antihypertenSive drug levels In patients with hypertensiON (DECISION), is to fill in this PK/PD knowledge gap and move towards precision dosing. DECISION is a prospective observational PK/PD study set up to determine the difference in exposure to the antihypertensive drugs, losartan and perindopril, measured by drug levels in blood. The area under the curve (AUC; PK) and furthermore the association between the AUC and the effect on blood pressure (PD) will be compared between elderly and younger patients.",

author = "Dimokrat Hassan and Peeters, \{Laura E.J.\} and Koch, \{Birgit C.P.\} and Jorie Versmissen",

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doi = "10.1007/s40292-022-00505-w",

language = "English",

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Hassan, D, Peeters, LEJ , Koch, BCP & Versmissen, J 2022, 'DiffErenCes in AntihypertenSive Drug Blood Levels in Patients with HypertensiON (DECISION): Protocol for a Prospective Observational Study Comparing Pharmacokinetics and Pharmacodynamics Between Young and Elderly Patients', High Blood Pressure and Cardiovascular Prevention, vol. 29, no. 3, pp. 239-243. https://doi.org/10.1007/s40292-022-00505-w

DiffErenCes in AntihypertenSive Drug Blood Levels in Patients with HypertensiON (DECISION): Protocol for a Prospective Observational Study Comparing Pharmacokinetics and Pharmacodynamics Between Young and Elderly Patients. / Hassan, Dimokrat; Peeters, Laura E.J.; Koch, Birgit C.P. et al.
In: High Blood Pressure and Cardiovascular Prevention, Vol. 29, No. 3, 05.2022, p. 239-243.

Research output: Contribution to journal › Article › Academic › peer-review

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Hassan D, Peeters LEJ , Koch BCP , Versmissen J. DiffErenCes in AntihypertenSive Drug Blood Levels in Patients with HypertensiON (DECISION): Protocol for a Prospective Observational Study Comparing Pharmacokinetics and Pharmacodynamics Between Young and Elderly Patients. High Blood Pressure and Cardiovascular Prevention. 2022 May;29(3):239-243. doi: 10.1007/s40292-022-00505-w

DiffErenCes in AntihypertenSive Drug Blood Levels in Patients with HypertensiON (DECISION): Protocol for a Prospective Observational Study Comparing Pharmacokinetics and Pharmacodynamics Between Young and Elderly Patients

Abstract

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