Differential effects of renin-angiotensine-aldosteron system inhibition, sympathoinhibition and low sodium diet on blood pressure in women with a history of preeclampsia: A double-blind, placebo-controlled cross-over trial (the PALM study)

Gerbrand A. Zoet; Nina D. Paauw; Jan H.W. Veerbeek; T. Katrien J. Groenhof; Wilko Spiering; Marianne C. Verhaar; A. Franx; A. Titia Lely

doi:10.1016/j.preghy.2021.12.016

Differential effects of renin-angiotensine-aldosteron system inhibition, sympathoinhibition and low sodium diet on blood pressure in women with a history of preeclampsia: A double-blind, placebo-controlled cross-over trial (the PALM study)

Gerbrand A. Zoet^*, Nina D. Paauw, Jan H.W. Veerbeek, T. Katrien J. Groenhof, Wilko Spiering, Marianne C. Verhaar, A. Franx, A. Titia Lely

^*Corresponding author for this work

Obstetrics & Gynecology

Research output: Contribution to journal › Article › Academic › peer-review

3 Citations (Scopus)

Abstract

Current guidelines lack sufficient evidence to recommend a specific blood pressure lowering strategy to prevent cardiovascular disease after preeclampsia. We conducted a double-blind cross-over trial to identify the most potent antihypertensive strategy: renin-angiotensin-aldosterone system (RAAS) inhibition (losartan), sympathoinhibition (moxonidine), low sodium diet and placebo (n = 10). Due to low inclusion rate our study stopped prematurely. Initiatory analyses showed no significant effect of antihypertensive strategy on office blood pressure and 24-hour blood pressure. However, nocturnal dipping was significantly higher on RAAS inhibition and low sodium diet compared to placebo and sympathoinhibition. Optimal cardiovascular prevention after preeclampsia should be further explored.

Original language	English
Pages (from-to)	173-175
Number of pages	3
Journal	Pregnancy Hypertension
Volume	27
Early online date	21 Jan 2022
DOIs	https://doi.org/10.1016/j.preghy.2021.12.016
Publication status	Published - Mar 2022

Bibliographical note

Publisher Copyright:
© 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.preghy.2021.12.016

Fingerprint

Dive into the research topics of 'Differential effects of renin-angiotensine-aldosteron system inhibition, sympathoinhibition and low sodium diet on blood pressure in women with a history of preeclampsia: A double-blind, placebo-controlled cross-over trial (the PALM study)'. Together they form a unique fingerprint.

Cite this

Zoet, G. A., Paauw, N. D., Veerbeek, J. H. W., Groenhof, T. K. J., Spiering, W., Verhaar, M. C., Franx, A., & Titia Lely, A. (2022). Differential effects of renin-angiotensine-aldosteron system inhibition, sympathoinhibition and low sodium diet on blood pressure in women with a history of preeclampsia: A double-blind, placebo-controlled cross-over trial (the PALM study). Pregnancy Hypertension, 27, 173-175. https://doi.org/10.1016/j.preghy.2021.12.016

@article{3ebe56cff10d4bc2bd789d825cba2603,

title = "Differential effects of renin-angiotensine-aldosteron system inhibition, sympathoinhibition and low sodium diet on blood pressure in women with a history of preeclampsia: A double-blind, placebo-controlled cross-over trial (the PALM study)",

abstract = "Current guidelines lack sufficient evidence to recommend a specific blood pressure lowering strategy to prevent cardiovascular disease after preeclampsia. We conducted a double-blind cross-over trial to identify the most potent antihypertensive strategy: renin-angiotensin-aldosterone system (RAAS) inhibition (losartan), sympathoinhibition (moxonidine), low sodium diet and placebo (n = 10). Due to low inclusion rate our study stopped prematurely. Initiatory analyses showed no significant effect of antihypertensive strategy on office blood pressure and 24-hour blood pressure. However, nocturnal dipping was significantly higher on RAAS inhibition and low sodium diet compared to placebo and sympathoinhibition. Optimal cardiovascular prevention after preeclampsia should be further explored.",

author = "Zoet, {Gerbrand A.} and Paauw, {Nina D.} and Veerbeek, {Jan H.W.} and Groenhof, {T. Katrien J.} and Wilko Spiering and Verhaar, {Marianne C.} and A. Franx and {Titia Lely}, A.",

note = "Publisher Copyright: {\textcopyright} 2022",

year = "2022",

month = mar,

doi = "10.1016/j.preghy.2021.12.016",

language = "English",

volume = "27",

pages = "173--175",

journal = "Pregnancy Hypertension",

issn = "2210-7789",

publisher = "Elsevier",

}

Zoet, GA, Paauw, ND, Veerbeek, JHW, Groenhof, TKJ, Spiering, W, Verhaar, MC, Franx, A & Titia Lely, A 2022, 'Differential effects of renin-angiotensine-aldosteron system inhibition, sympathoinhibition and low sodium diet on blood pressure in women with a history of preeclampsia: A double-blind, placebo-controlled cross-over trial (the PALM study)', Pregnancy Hypertension, vol. 27, pp. 173-175. https://doi.org/10.1016/j.preghy.2021.12.016

Differential effects of renin-angiotensine-aldosteron system inhibition, sympathoinhibition and low sodium diet on blood pressure in women with a history of preeclampsia: A double-blind, placebo-controlled cross-over trial (the PALM study). / Zoet, Gerbrand A.; Paauw, Nina D.; Veerbeek, Jan H.W. et al.
In: Pregnancy Hypertension, Vol. 27, 03.2022, p. 173-175.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Differential effects of renin-angiotensine-aldosteron system inhibition, sympathoinhibition and low sodium diet on blood pressure in women with a history of preeclampsia

T2 - A double-blind, placebo-controlled cross-over trial (the PALM study)

AU - Zoet, Gerbrand A.

AU - Paauw, Nina D.

AU - Veerbeek, Jan H.W.

AU - Groenhof, T. Katrien J.

AU - Spiering, Wilko

AU - Verhaar, Marianne C.

AU - Franx, A.

AU - Titia Lely, A.

PY - 2022/3

Y1 - 2022/3

N2 - Current guidelines lack sufficient evidence to recommend a specific blood pressure lowering strategy to prevent cardiovascular disease after preeclampsia. We conducted a double-blind cross-over trial to identify the most potent antihypertensive strategy: renin-angiotensin-aldosterone system (RAAS) inhibition (losartan), sympathoinhibition (moxonidine), low sodium diet and placebo (n = 10). Due to low inclusion rate our study stopped prematurely. Initiatory analyses showed no significant effect of antihypertensive strategy on office blood pressure and 24-hour blood pressure. However, nocturnal dipping was significantly higher on RAAS inhibition and low sodium diet compared to placebo and sympathoinhibition. Optimal cardiovascular prevention after preeclampsia should be further explored.

AB - Current guidelines lack sufficient evidence to recommend a specific blood pressure lowering strategy to prevent cardiovascular disease after preeclampsia. We conducted a double-blind cross-over trial to identify the most potent antihypertensive strategy: renin-angiotensin-aldosterone system (RAAS) inhibition (losartan), sympathoinhibition (moxonidine), low sodium diet and placebo (n = 10). Due to low inclusion rate our study stopped prematurely. Initiatory analyses showed no significant effect of antihypertensive strategy on office blood pressure and 24-hour blood pressure. However, nocturnal dipping was significantly higher on RAAS inhibition and low sodium diet compared to placebo and sympathoinhibition. Optimal cardiovascular prevention after preeclampsia should be further explored.

UR - http://www.scopus.com/inward/record.url?scp=85123107568&partnerID=8YFLogxK

U2 - 10.1016/j.preghy.2021.12.016

DO - 10.1016/j.preghy.2021.12.016

M3 - Article

C2 - 35074611

AN - SCOPUS:85123107568

SN - 2210-7789

VL - 27

SP - 173

EP - 175

JO - Pregnancy Hypertension

JF - Pregnancy Hypertension

ER -

Zoet GA, Paauw ND, Veerbeek JHW, Groenhof TKJ, Spiering W, Verhaar MC et al. Differential effects of renin-angiotensine-aldosteron system inhibition, sympathoinhibition and low sodium diet on blood pressure in women with a history of preeclampsia: A double-blind, placebo-controlled cross-over trial (the PALM study). Pregnancy Hypertension. 2022 Mar;27:173-175. Epub 2022 Jan 21. doi: 10.1016/j.preghy.2021.12.016

Differential effects of renin-angiotensine-aldosteron system inhibition, sympathoinhibition and low sodium diet on blood pressure in women with a history of preeclampsia: A double-blind, placebo-controlled cross-over trial (the PALM study)

Abstract

Bibliographical note

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this