Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels

Sidiq Widagdo; Stalinraj Victor; Debby van Eck - Schipper; Kimberley Kolijn; Arno van Leenders; BJ Bosch; A Bensaid; J Segales; W Baumgartner; Ab Osterhaus; Marion Koopmans; Judith van den Brand; Bart Haagmans

doi:10.1128/JVI.02994-15

Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels

Sidiq Widagdo, Stalinraj Victor, Debby van Eck - Schipper, Kimberley Kolijn, Arno van Leenders, BJ Bosch, A Bensaid, J Segales, W Baumgartner, Ab Osterhaus, Marion Koopmans, Judith van den Brand, Bart Haagmans

Research output: Contribution to journal › Article › Academic › peer-review

97 Citations (Scopus)

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) is not efficiently transmitted between humans, but it is highly prevalent in dromedary camels. Here we report that the MERS-CoV receptor-dipeptidyl peptidase 4 (DPP4)-is expressed in the upper respiratory tract epithelium of camels but not in that of humans. Lack of DPP4 expression may be the primary cause of limited MERS-CoV replication in the human upper respiratory tract and hence restrict transmission.

Original language	Undefined/Unknown
Pages (from-to)	4838-4842
Number of pages	5
Journal	Journal of Virology
Volume	90
Issue number	9
DOIs	https://doi.org/10.1128/JVI.02994-15
Publication status	Published - 2016

Research programs

EMC MM-03-24-01
EMC MM-04-27-01

Access to Document

10.1128/JVI.02994-15

http://hdl.handle.net/1765/90296

Cite this

Widagdo, S., Victor, S., van Eck - Schipper, D., Kolijn, K., van Leenders, A., Bosch, BJ., Bensaid, A., Segales, J., Baumgartner, W., Osterhaus, A., Koopmans, M., van den Brand, J., & Haagmans, B. (2016). Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels. Journal of Virology, 90(9), 4838-4842. https://doi.org/10.1128/JVI.02994-15

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abstract = "Middle East respiratory syndrome coronavirus (MERS-CoV) is not efficiently transmitted between humans, but it is highly prevalent in dromedary camels. Here we report that the MERS-CoV receptor-dipeptidyl peptidase 4 (DPP4)-is expressed in the upper respiratory tract epithelium of camels but not in that of humans. Lack of DPP4 expression may be the primary cause of limited MERS-CoV replication in the human upper respiratory tract and hence restrict transmission.",

author = "Sidiq Widagdo and Stalinraj Victor and {van Eck - Schipper}, Debby and Kimberley Kolijn and {van Leenders}, Arno and BJ Bosch and A Bensaid and J Segales and W Baumgartner and Ab Osterhaus and Marion Koopmans and {van den Brand}, Judith and Bart Haagmans",

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Widagdo, S, Victor, S, van Eck - Schipper, D, Kolijn, K, van Leenders, A, Bosch, BJ, Bensaid, A, Segales, J, Baumgartner, W, Osterhaus, A, Koopmans, M , van den Brand, J & Haagmans, B 2016, 'Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels', Journal of Virology, vol. 90, no. 9, pp. 4838-4842. https://doi.org/10.1128/JVI.02994-15

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T1 - Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels

AU - Widagdo, Sidiq

AU - Victor, Stalinraj

AU - van Eck - Schipper, Debby

AU - Kolijn, Kimberley

AU - van Leenders, Arno

AU - Bosch, BJ

AU - Bensaid, A

AU - Segales, J

AU - Baumgartner, W

AU - Osterhaus, Ab

AU - Koopmans, Marion

AU - van den Brand, Judith

AU - Haagmans, Bart

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AB - Middle East respiratory syndrome coronavirus (MERS-CoV) is not efficiently transmitted between humans, but it is highly prevalent in dromedary camels. Here we report that the MERS-CoV receptor-dipeptidyl peptidase 4 (DPP4)-is expressed in the upper respiratory tract epithelium of camels but not in that of humans. Lack of DPP4 expression may be the primary cause of limited MERS-CoV replication in the human upper respiratory tract and hence restrict transmission.

U2 - 10.1128/JVI.02994-15

DO - 10.1128/JVI.02994-15

M3 - Article

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