Differentiation of femur bone from surrounding soft tissue using laser-induced breakdown spectroscopy as a feedback system for smart laserosteotomy

Hamed Abbasi, Georg Rauter, Raphael Guzman, Philippe C. Cattin, Azhar Zam

Research output: Chapter/Conference proceedingConference proceedingAcademicpeer-review

17 Citations (Scopus)

Abstract

Although laserosteotomes have become generally accepted devices in surgical applications, they still suffer from a lack of information about the type of tissue currently being ablated; as a result, critical structures of the body under or near the focal spot of the laser beam are prone to inadvertent ablation. The lack of information about the properties of the ablated tissue can be solved by connecting the laserosteotome to an optical detection setup which can differentiate various types of tissues, especially bone from connective soft tissues. This study examines the applicability of laser-induced breakdown spectroscopy (LIBS) as a potential technique to differentiate bone from surrounding soft tissue (fat and muscle). In this experiment, fresh porcine femur bone, muscle, and fat were used as hard and soft tissue samples. The beam of a nanosecond frequency-doubled Nd:YAG laser was used to ablate the tissue samples and generate the plasma. The plasma light emitted from the ablated spot, which corresponds to the recombination spectra of ionized atoms and molecules, was gathered with a collection optic (including a reflective light collector and a fiber optic) and sent to an Echelle spectrometer for resolving the atomic composition of the ablated sample. Afterwards, Discriminant Function Analysis (DFA) based on the ratio of the intensity of selected peak pairs was performed to classify three sample groups (bone, muscle, and fat). Lastly, the sensitivity, specificity, and accuracy of the proposed method were calculated. Sensitivity and specificity of 100 % and 99 % were achieved, respectively, to differentiate bone from surrounding soft tissue.

Original languageEnglish
Title of host publicationBiophotonics
Subtitle of host publicationPhotonic Solutions for Better Health Care VI
EditorsJurgen Popp, Valery V. Tuchin, Francesco Saverio Pavone
PublisherSPIE
ISBN (Electronic)9781510618961
DOIs
Publication statusPublished - 2018
Externally publishedYes
EventBiophotonics: Photonic Solutions for Better Health Care VI 2018 - Strasbourg, France
Duration: 23 Apr 201826 Apr 2018

Publication series

SeriesProceedings of SPIE - The International Society for Optical Engineering
Volume10685
ISSN0277-786X

Conference

ConferenceBiophotonics: Photonic Solutions for Better Health Care VI 2018
Country/TerritoryFrance
CityStrasbourg
Period23/04/1826/04/18

Bibliographical note

Funding Information:
The authors gratefully acknowledge funding of the Werner Siemens Foundation through the Minimally Invasive Robot-Assisted Computer-guided LaserosteotomE (MIRACLE) project. In addition, the authors appreciate the assistance given by Dr. Maryam Bahreini.

Publisher Copyright: © 2018 SPIE.

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