Differentiation of hepatocellular adenoma and focal nodular hyperplasia using 18F-fluorocholine PET/CT

Jacomina W. Van Den Esschert; Matthanja Bieze; Ulrich H. Beuers; Thomas M. Van Gulik; Roelof J. Bennink

doi:10.1007/s00259-010-1584-0

Differentiation of hepatocellular adenoma and focal nodular hyperplasia using ¹⁸F-fluorocholine PET/CT

Jacomina W. Van Den Esschert
, Matthanja Bieze
, Ulrich H. Beuers
, Thomas M. Van Gulik^*
, Roelof J. Bennink

^*Corresponding author for this work

Amsterdam UMC

Research output: Contribution to journal › Article › Academic › peer-review

26 Citations (Scopus)

Abstract

The aim of this pilot study was to evaluate the use of PET/CT with ¹⁸F-fluorocholine in the differentiation of hepatocellular adenoma (HCA) from focal nodular hyperplasia (FNH). Patients with liver lesions larger than 2 cm suspicious for HCA or FNH were prospectively included. All patients underwent PET/CT with ¹⁸F-fluorocholine and histopathological diagnosis was obtained by either liver biopsy or surgery. The ratios between the maximum standardized uptake value (SUV) of the lesion and the mean SUV of normal liver parenchyma were calculated and a receiver operating characteristic (ROC) curve analysis was performed. Ten patients with FNH and 11 with HCA were included. The mean SUV ratio was 1.68±0.29 (±SD) for FNH and 0.88±0.18 for HCA (p<0.001). An SUV ratio cutoff value between 1.12 and 1.22 differentiated patients with FNH from those with HCA with 100% sensitivity and 100% specificity. This pilot study showed that PET/CT with ¹⁸Ffluorocholine can differentiate HCA from FNH.

Original language	English
Pages (from-to)	436-440
Number of pages	5
Journal	European Journal of Nuclear Medicine and Molecular Imaging
Volume	38
Issue number	3
DOIs	https://doi.org/10.1007/s00259-010-1584-0
Publication status	Published - Mar 2011
Externally published	Yes

Access to Document

10.1007/s00259-010-1584-0Licence: CC BY-NC

Differentiation of hepatocellular adenoma and focal nodular hyperplasia using 18F-fluorocholine PET CTFinal published version, 196 KBLicence: CC BY-NC

Cite this

@article{eda63d34259d41cd92b5e72cd2bec3d4,

title = "Differentiation of hepatocellular adenoma and focal nodular hyperplasia using 18F-fluorocholine PET/CT",

abstract = "The aim of this pilot study was to evaluate the use of PET/CT with 18F-fluorocholine in the differentiation of hepatocellular adenoma (HCA) from focal nodular hyperplasia (FNH). Patients with liver lesions larger than 2 cm suspicious for HCA or FNH were prospectively included. All patients underwent PET/CT with 18F-fluorocholine and histopathological diagnosis was obtained by either liver biopsy or surgery. The ratios between the maximum standardized uptake value (SUV) of the lesion and the mean SUV of normal liver parenchyma were calculated and a receiver operating characteristic (ROC) curve analysis was performed. Ten patients with FNH and 11 with HCA were included. The mean SUV ratio was 1.68±0.29 (±SD) for FNH and 0.88±0.18 for HCA (p<0.001). An SUV ratio cutoff value between 1.12 and 1.22 differentiated patients with FNH from those with HCA with 100\% sensitivity and 100\% specificity. This pilot study showed that PET/CT with 18Ffluorocholine can differentiate HCA from FNH.",

author = "\{Van Den Esschert\}, \{Jacomina W.\} and Matthanja Bieze and Beuers, \{Ulrich H.\} and \{Van Gulik\}, \{Thomas M.\} and Bennink, \{Roelof J.\}",

year = "2011",

month = mar,

doi = "10.1007/s00259-010-1584-0",

language = "English",

volume = "38",

pages = "436--440",

journal = "European Journal of Nuclear Medicine and Molecular Imaging",

issn = "1619-7070",

number = "3",

}

TY - JOUR

T1 - Differentiation of hepatocellular adenoma and focal nodular hyperplasia using 18F-fluorocholine PET/CT

AU - Van Den Esschert, Jacomina W.

AU - Bieze, Matthanja

AU - Beuers, Ulrich H.

AU - Van Gulik, Thomas M.

AU - Bennink, Roelof J.

PY - 2011/3

Y1 - 2011/3

N2 - The aim of this pilot study was to evaluate the use of PET/CT with 18F-fluorocholine in the differentiation of hepatocellular adenoma (HCA) from focal nodular hyperplasia (FNH). Patients with liver lesions larger than 2 cm suspicious for HCA or FNH were prospectively included. All patients underwent PET/CT with 18F-fluorocholine and histopathological diagnosis was obtained by either liver biopsy or surgery. The ratios between the maximum standardized uptake value (SUV) of the lesion and the mean SUV of normal liver parenchyma were calculated and a receiver operating characteristic (ROC) curve analysis was performed. Ten patients with FNH and 11 with HCA were included. The mean SUV ratio was 1.68±0.29 (±SD) for FNH and 0.88±0.18 for HCA (p<0.001). An SUV ratio cutoff value between 1.12 and 1.22 differentiated patients with FNH from those with HCA with 100% sensitivity and 100% specificity. This pilot study showed that PET/CT with 18Ffluorocholine can differentiate HCA from FNH.

AB - The aim of this pilot study was to evaluate the use of PET/CT with 18F-fluorocholine in the differentiation of hepatocellular adenoma (HCA) from focal nodular hyperplasia (FNH). Patients with liver lesions larger than 2 cm suspicious for HCA or FNH were prospectively included. All patients underwent PET/CT with 18F-fluorocholine and histopathological diagnosis was obtained by either liver biopsy or surgery. The ratios between the maximum standardized uptake value (SUV) of the lesion and the mean SUV of normal liver parenchyma were calculated and a receiver operating characteristic (ROC) curve analysis was performed. Ten patients with FNH and 11 with HCA were included. The mean SUV ratio was 1.68±0.29 (±SD) for FNH and 0.88±0.18 for HCA (p<0.001). An SUV ratio cutoff value between 1.12 and 1.22 differentiated patients with FNH from those with HCA with 100% sensitivity and 100% specificity. This pilot study showed that PET/CT with 18Ffluorocholine can differentiate HCA from FNH.

UR - https://www.scopus.com/pages/publications/79953736361

U2 - 10.1007/s00259-010-1584-0

DO - 10.1007/s00259-010-1584-0

M3 - Article

C2 - 20717825

AN - SCOPUS:79953736361

SN - 1619-7070

VL - 38

SP - 436

EP - 440

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

IS - 3

ER -

Differentiation of hepatocellular adenoma and focal nodular hyperplasia using ¹⁸F-fluorocholine PET/CT

Abstract

Access to Document

Other files and links

Fingerprint

Cite this