Direct comparison of SARS-CoV-2 variant specific neutralizing antibodies in human and hamster sera

Annika Rössler; Antonia Netzl; Ludwig Knabl; Samuel H. Wilks; Barbara Mühlemann; Sina Türeli; Anna Mykytyn; Dorothee von Laer; Bart L. Haagmans; Derek J. Smith; Janine Kimpel

doi:10.1038/s41541-024-00888-y

Direct comparison of SARS-CoV-2 variant specific neutralizing antibodies in human and hamster sera

Annika Rössler
, Antonia Netzl
, Ludwig Knabl
, Samuel H. Wilks
, Barbara Mühlemann
, Sina Türeli
, Anna Mykytyn
, Dorothee von Laer
, Bart L. Haagmans
, Derek J. Smith^*
, Janine Kimpel^*

^*Corresponding author for this work

Virology

Innsbruck Medical University
Hebrew SeniorLife
University of Cambridge
Tyrolpath Obrist Brunhuber GmbH
Charité – Universitätsmedizin Berlin

Research output: Contribution to journal › Article › Academic › peer-review

9 Citations (Scopus)

32 Downloads (Pure)

Abstract

Antigenic characterization of newly emerging SARS-CoV-2 variants is important to assess their immune escape and judge the need for future vaccine updates. To bridge data obtained from animal sera with human sera, we analyzed neutralizing antibody titers in human and hamster single infection sera in a highly controlled setting using the same authentic virus neutralization assay performed in one laboratory. Using a Bayesian framework, we found that titer fold changes in hamster sera corresponded well to human sera and that hamster sera generally exhibited higher reactivity.

Original language	English
Article number	85
Journal	npj Vaccines
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/s41541-024-00888-y
Publication status	Published - 18 May 2024

Bibliographical note

Publisher Copyright: © The Author(s) 2024.

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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s41541-024-00888-yFinal published version, 1.38 MBLicence: CC BY

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title = "Direct comparison of SARS-CoV-2 variant specific neutralizing antibodies in human and hamster sera",

abstract = "Antigenic characterization of newly emerging SARS-CoV-2 variants is important to assess their immune escape and judge the need for future vaccine updates. To bridge data obtained from animal sera with human sera, we analyzed neutralizing antibody titers in human and hamster single infection sera in a highly controlled setting using the same authentic virus neutralization assay performed in one laboratory. Using a Bayesian framework, we found that titer fold changes in hamster sera corresponded well to human sera and that hamster sera generally exhibited higher reactivity.",

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AU - Netzl, Antonia

AU - Knabl, Ludwig

AU - Wilks, Samuel H.

AU - Mühlemann, Barbara

AU - Türeli, Sina

AU - Mykytyn, Anna

AU - von Laer, Dorothee

AU - Haagmans, Bart L.

AU - Smith, Derek J.

AU - Kimpel, Janine

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AB - Antigenic characterization of newly emerging SARS-CoV-2 variants is important to assess their immune escape and judge the need for future vaccine updates. To bridge data obtained from animal sera with human sera, we analyzed neutralizing antibody titers in human and hamster single infection sera in a highly controlled setting using the same authentic virus neutralization assay performed in one laboratory. Using a Bayesian framework, we found that titer fold changes in hamster sera corresponded well to human sera and that hamster sera generally exhibited higher reactivity.

UR - https://www.scopus.com/pages/publications/85193545863

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ER -

Direct comparison of SARS-CoV-2 variant specific neutralizing antibodies in human and hamster sera

Abstract

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