Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010

CJL Murray, T de Vos, R Lozano, M Naghavi, AD Flaxman, C Michaud, M Ezzati, K Shibuya, JA Salomon, S Abdalla, V Aboyans, J Abraham, I Ackerman, R Aggarwal, SY Ahn, MK Ali, M Alvarado, HR Anderson, LM Anderson, KG AndrewsC Atkinson, LM Baddour, AN Bahalim, S Barker-Collo, LH Barrero, DH Bartels, MG Basanez, A Baxter, ML Bell, EJ Benjamin, D Bennett, E Bernabe, K Bhalla, B Bhandari, B Bikbov, A Bin Abdulhak, G Birbeck, JA Black, H Blencowe, JD Blore, F Blyth, I Bolliger, A Bonaventure, SA Boufous, R Bourne, M Boussinesq, T Braithwaite, C Brayne, L Bridgett, S Brooker, P Brooks, TS Brugha, C Bryan-Hancock, C Bucello, R Buchbinder, G Buckle, CM Budke, M Burch, P Burney, R Burstein, B Calabria, B Campbell, CE Canter, H Carabin, J Carapetis, L Carmona, C Cella, F Charlson, HL Chen, ATA Cheng, D Chou, SS Chugh, Luc Coffeng, SD Colan, S Colquhoun, KE Colson, J Condon, MD Connor, LT Cooper, M Corriere, M Cortinovis, KC de Vaccaro, W Couser, BC Cowie, MH Criqui, M Cross, KC Dabhadkar, M Dahiya, N Dahodwala, J Damsere-Derry, G Danaei, A Davis, D De Leo, L Degenhardt, R Dellavalle, A Delossantos, J Denenberg, S Derrett, DC Des Jarlais, SD Dharmaratne, M Dherani, C Diaz-Torne, H Dolk, ER Dorsey, T Driscoll, H Duber, B Ebel, K Edmond, A Elbaz, SE Ali, H Erskine, PJ Erwin, P Espindola, SE Ewoigbokhan, F Farzadfar, V Feigin, DT Felson, A Ferrari, CP Ferri, EM Fevre, MM Finucane, S Flaxman, L Flood, K Foreman, MH Forouzanfar, FGR Fowkes, Mirjam Fransen, MK Freeman, BJ Gabbe, SE Gabriel, E Gakidou, HA Ganatra, B Garcia, F Gaspari, RF Gillum, G Gmel, D Gonzalez-Medina, R Gosselin, R Grainger, B Grant, J Groeger, F Guillemin, D Gunnell, R Gupta, J Haagsma, H Hagan, YA Halasa, W Hall, D Haring, JM Haro, JE Harrison, R Havmoeller, RJ Hay, H Higashi, C Hill, B Hoen, H Hoffman, PJ Hotez, D Hoy, JJ Huang, SE Ibeanusi, KH Jacobsen, SL James, D Jarvis, R Jasrasaria, S Jayaraman, N Johns, JB Jonas, G Karthikeyan, N Kassebaum, N Kawakami, A Keren, JP Khoo, CH King, LM Knowlton, O Kobusingye, A Koranteng, R Krishnamurthi, F Laden, R Lalloo, LL Laslett, T Lathlean, JL Leasher, YY Lee, J Leigh, D Levinson, SS Lim, E Limb, JK Lin, M Lipnick, SE Lipshultz, W (Wei) Liu, M Loane, SL Ohno, R Lyons, J Mabweijano, MF MacIntyre, R Malekzadeh, L Mallinger, S Manivannan, W Marcenes, L March, DJ Margolis, GB Marks, R Marks, A Matsumori, R Matzopoulos, BM Mayosi, JH McAnulty, MM McDermott, N McGill, J McGrath, ME Medina-Mora, M Meltzer, GA Mensah, TR Merriman, AC Meyer, V Miglioli, M Miller, TR Miller, PB Mitchell, C Mock, AO Mocumbi, TE Moffitt, AA Mokdad, L Monasta, M Montico, M Moradi-Lakeh, A Moran, L Morawska, R Mori, ME Murdoch, MK Mwaniki, K Naidoo, MN Nair, L Naldi, KMV Narayan, PK Nelson, RG Nelson, MC Nevitt, CR Newton, S Nolte, P Norman, R Norman, M O'Donnell, Simon O'Hanlon, C Olives, SB Omer, K Ortblad, R Osborne, D Ozgediz, A Page, B Pahari, JD Pandian, AP Rivero, SB Patten, N Pearce, RP Padilla, F Perez-Ruiz, N Perico, K Pesudovs, D Phillips, MR Phillips, K Pierce, S Pion, GV Polanczyk, Suzanne Polinder, CA Pope, S Popova, E Porrini, F Pourmalek, M Prince, RL Pullan, KD Ramaiah, D Ranganathan, H Razavi, M Regan, JT Rehm, DB Rein, G Remuzzi, K Richardson, FP Rivara, T Roberts, C Robinson, FR De Leon, L Ronfani, R Room, LC Rosenfeld, L Rushton, RL Sacco, S Saha, U Sampson, L Sanchez-Riera, E Sanman, DC Schwebel, JG Scott, M Segui-Gomez, S Shahraz, DS Shepard, H Shin, R Shivakoti, D Singh, GM Singh, JA Singh, J Singleton, DA Sleet, K Sliwa, E Smith, JL Smith, NJC Stapelberg, A Steer, T Steiner, Wilma Stolk, LJ Stovner, C Sudfeld, S Syed, G Tamburlini, M Tavakkoli, HR Taylor, JA Taylor, WJ Taylor, B Thomas, WM Thomson, GD Thurston, IM Tleyjeh, M Tonelli, JRA Towbin, T Truelsen, MK Tsilimbaris, C Ubeda, EA Undurraga, MJ (Marieke) van der Werf, J van Os, MS Vavilala, N Venketasubramanian, MR Wang, WZ Wang, K Watt, DJ Weatherall, MA Weinstock, R Weintraub, MG Weisskopf, MM Weissman, RA White, H Whiteford, N Wiebe, ST Wiersma, JD Wilkinson, HC Williams, SRM Williams, E Witt, F Wolfe, AD Woolf, S Wulf, PH Yeh, AKM Zaidi, ZJ Zheng, D Zonies, AD Lopez

Research output: Contribution to journalArticleAcademicpeer-review

6309 Citations (Scopus)

Abstract

Background Measuring disease and injury burden in populations requires a composite metric that captures both premature mortality and the prevalence and severity of ill-health. The 1990 Global Burden of Disease study proposed disability-adjusted life years (DALYs) to measure disease burden. No comprehensive update of disease burden worldwide incorporating a systematic reassessment of disease and injury-specific epidemiology has been done since the 1990 study. We aimed to calculate disease burden worldwide and for 21 regions for 1990, 2005, and 2010 with methods to enable meaningful comparisons over time. Methods We calculated DALYs as the sum of years of life lost (YLLs) and years lived with disability (YLDs). DALYs were calculated for 291 causes, 20 age groups, both sexes, and for 187 countries, and aggregated to regional and global estimates of disease burden for three points in time with strictly comparable definitions and methods. YLLs were calculated from age-sex-country-time-specific estimates of mortality by cause, with death by standardised lost life expectancy at each age. YLDs were cal Findings Global DALYs remained stable from 1990 (2.503 billion) to 2010 (2.490 billion). Crude DALYs per 1000 decreased by 23% (472 per 1000 to 361 per 1000). An important shift has occurred in DALY composition with the contribution of deaths and disability among children (younger than 5 years of age) declining from 41% of global DALYs in 1990 to 25% in 2010. YLLs typically account for about half of disease burden in more developed regions (high-income Asia Pacific, western Europe, high-income N Interpretation Global disease burden has continued to shift away from communicable to non-communicable diseases and from premature death to years lived with disability. In sub-Saharan Africa, however, many communicable, maternal, neonatal, and nutritional disorders remain the dominant causes of disease burden. The rising burden from mental and behavioural disorders, musculoskeletal disorders, and diabetes will impose new challenges on health systems. Regional heterogeneity highlights the importa
Original languageUndefined/Unknown
Pages (from-to)2197-2223
Number of pages27
JournalLancet (UK)
Volume380
Issue number9859
DOIs
Publication statusPublished - 2012

Cite this