Abstract
| Original language | Undefined/Unknown |
|---|---|
| Pages (from-to) | 2197-2223 |
| Number of pages | 27 |
| Journal | Lancet (UK) |
| Volume | 380 |
| Issue number | 9859 |
| DOIs | |
| Publication status | Published - 2012 |
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Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. / Murray, CJL; de Vos, T; Lozano, R et al.
In: Lancet (UK), Vol. 380, No. 9859, 2012, p. 2197-2223.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010
AU - Murray, CJL
AU - de Vos, T
AU - Lozano, R
AU - Naghavi, M
AU - Flaxman, AD
AU - Michaud, C
AU - Ezzati, M
AU - Shibuya, K
AU - Salomon, JA
AU - Abdalla, S
AU - Aboyans, V
AU - Abraham, J
AU - Ackerman, I
AU - Aggarwal, R
AU - Ahn, SY
AU - Ali, MK
AU - Alvarado, M
AU - Anderson, HR
AU - Anderson, LM
AU - Andrews, KG
AU - Atkinson, C
AU - Baddour, LM
AU - Bahalim, AN
AU - Barker-Collo, S
AU - Barrero, LH
AU - Bartels, DH
AU - Basanez, MG
AU - Baxter, A
AU - Bell, ML
AU - Benjamin, EJ
AU - Bennett, D
AU - Bernabe, E
AU - Bhalla, K
AU - Bhandari, B
AU - Bikbov, B
AU - Bin Abdulhak, A
AU - Birbeck, G
AU - Black, JA
AU - Blencowe, H
AU - Blore, JD
AU - Blyth, F
AU - Bolliger, I
AU - Bonaventure, A
AU - Boufous, SA
AU - Bourne, R
AU - Boussinesq, M
AU - Braithwaite, T
AU - Brayne, C
AU - Bridgett, L
AU - Brooker, S
AU - Brooks, P
AU - Brugha, TS
AU - Bryan-Hancock, C
AU - Bucello, C
AU - Buchbinder, R
AU - Buckle, G
AU - Budke, CM
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AU - Burney, P
AU - Burstein, R
AU - Calabria, B
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AU - Canter, CE
AU - Carabin, H
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AU - Carmona, L
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AU - Charlson, F
AU - Chen, HL
AU - Cheng, ATA
AU - Chou, D
AU - Chugh, SS
AU - Coffeng, Luc
AU - Colan, SD
AU - Colquhoun, S
AU - Colson, KE
AU - Condon, J
AU - Connor, MD
AU - Cooper, LT
AU - Corriere, M
AU - Cortinovis, M
AU - de Vaccaro, KC
AU - Couser, W
AU - Cowie, BC
AU - Criqui, MH
AU - Cross, M
AU - Dabhadkar, KC
AU - Dahiya, M
AU - Dahodwala, N
AU - Damsere-Derry, J
AU - Danaei, G
AU - Davis, A
AU - De Leo, D
AU - Degenhardt, L
AU - Dellavalle, R
AU - Delossantos, A
AU - Denenberg, J
AU - Derrett, S
AU - Des Jarlais, DC
AU - Dharmaratne, SD
AU - Dherani, M
AU - Diaz-Torne, C
AU - Dolk, H
AU - Dorsey, ER
AU - Driscoll, T
AU - Duber, H
AU - Ebel, B
AU - Edmond, K
AU - Elbaz, A
AU - Ali, SE
AU - Erskine, H
AU - Erwin, PJ
AU - Espindola, P
AU - Ewoigbokhan, SE
AU - Farzadfar, F
AU - Feigin, V
AU - Felson, DT
AU - Ferrari, A
AU - Ferri, CP
AU - Fevre, EM
AU - Finucane, MM
AU - Flaxman, S
AU - Flood, L
AU - Foreman, K
AU - Forouzanfar, MH
AU - Fowkes, FGR
AU - Fransen, Mirjam
AU - Freeman, MK
AU - Gabbe, BJ
AU - Gabriel, SE
AU - Gakidou, E
AU - Ganatra, HA
AU - Garcia, B
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AU - Roberts, T
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AU - Towbin, JRA
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AU - Ubeda, C
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AU - van der Werf, MJ (Marieke)
AU - van Os, J
AU - Vavilala, MS
AU - Venketasubramanian, N
AU - Wang, MR
AU - Wang, WZ
AU - Watt, K
AU - Weatherall, DJ
AU - Weinstock, MA
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AU - Zaidi, AKM
AU - Zheng, ZJ
AU - Zonies, D
AU - Lopez, AD
PY - 2012
Y1 - 2012
N2 - Background Measuring disease and injury burden in populations requires a composite metric that captures both premature mortality and the prevalence and severity of ill-health. The 1990 Global Burden of Disease study proposed disability-adjusted life years (DALYs) to measure disease burden. No comprehensive update of disease burden worldwide incorporating a systematic reassessment of disease and injury-specific epidemiology has been done since the 1990 study. We aimed to calculate disease burden worldwide and for 21 regions for 1990, 2005, and 2010 with methods to enable meaningful comparisons over time. Methods We calculated DALYs as the sum of years of life lost (YLLs) and years lived with disability (YLDs). DALYs were calculated for 291 causes, 20 age groups, both sexes, and for 187 countries, and aggregated to regional and global estimates of disease burden for three points in time with strictly comparable definitions and methods. YLLs were calculated from age-sex-country-time-specific estimates of mortality by cause, with death by standardised lost life expectancy at each age. YLDs were cal Findings Global DALYs remained stable from 1990 (2.503 billion) to 2010 (2.490 billion). Crude DALYs per 1000 decreased by 23% (472 per 1000 to 361 per 1000). An important shift has occurred in DALY composition with the contribution of deaths and disability among children (younger than 5 years of age) declining from 41% of global DALYs in 1990 to 25% in 2010. YLLs typically account for about half of disease burden in more developed regions (high-income Asia Pacific, western Europe, high-income N Interpretation Global disease burden has continued to shift away from communicable to non-communicable diseases and from premature death to years lived with disability. In sub-Saharan Africa, however, many communicable, maternal, neonatal, and nutritional disorders remain the dominant causes of disease burden. The rising burden from mental and behavioural disorders, musculoskeletal disorders, and diabetes will impose new challenges on health systems. Regional heterogeneity highlights the importa
AB - Background Measuring disease and injury burden in populations requires a composite metric that captures both premature mortality and the prevalence and severity of ill-health. The 1990 Global Burden of Disease study proposed disability-adjusted life years (DALYs) to measure disease burden. No comprehensive update of disease burden worldwide incorporating a systematic reassessment of disease and injury-specific epidemiology has been done since the 1990 study. We aimed to calculate disease burden worldwide and for 21 regions for 1990, 2005, and 2010 with methods to enable meaningful comparisons over time. Methods We calculated DALYs as the sum of years of life lost (YLLs) and years lived with disability (YLDs). DALYs were calculated for 291 causes, 20 age groups, both sexes, and for 187 countries, and aggregated to regional and global estimates of disease burden for three points in time with strictly comparable definitions and methods. YLLs were calculated from age-sex-country-time-specific estimates of mortality by cause, with death by standardised lost life expectancy at each age. YLDs were cal Findings Global DALYs remained stable from 1990 (2.503 billion) to 2010 (2.490 billion). Crude DALYs per 1000 decreased by 23% (472 per 1000 to 361 per 1000). An important shift has occurred in DALY composition with the contribution of deaths and disability among children (younger than 5 years of age) declining from 41% of global DALYs in 1990 to 25% in 2010. YLLs typically account for about half of disease burden in more developed regions (high-income Asia Pacific, western Europe, high-income N Interpretation Global disease burden has continued to shift away from communicable to non-communicable diseases and from premature death to years lived with disability. In sub-Saharan Africa, however, many communicable, maternal, neonatal, and nutritional disorders remain the dominant causes of disease burden. The rising burden from mental and behavioural disorders, musculoskeletal disorders, and diabetes will impose new challenges on health systems. Regional heterogeneity highlights the importa
U2 - 10.1016/S0140-6736(12)61689-4
DO - 10.1016/S0140-6736(12)61689-4
M3 - Article
VL - 380
SP - 2197
EP - 2223
JO - The Lancet
JF - The Lancet
SN - 0140-6736
IS - 9859
ER -