Abstract
The subject of this thesis is the role of rare genetic variation in the etiology of psychiatric disorders. The studies included in this work include a human genetics study on depression, a disease-modeling study for autism spectrum disorder using brain organoids, and the generation of an in vitro cellular drug-screening platform for schizophrenia. The research participants in these studies come from the genetically isolated Amish and Mennonite populations.
Original language | English |
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Award date | 28 Sept 2021 |
Place of Publication | Rotterdam |
Publication status | Published - 28 Sept 2021 |