Discovery and Neurobiological Modeling of Rare Genetic Variant Risk for Mental Illness

Job De Jong

Research output: Types of ThesisDoctoral ThesisInternal

Abstract

The subject of this thesis is the role of rare genetic variation in the etiology of psychiatric disorders. The studies included in this work include a human genetics study on depression, a disease-modeling study for autism spectrum disorder using brain organoids, and the generation of an in vitro cellular drug-screening platform for schizophrenia. The research participants in these studies come from the genetically isolated Amish and Mennonite populations.
Original languageEnglish
Awarding Institution
  • Erasmus University Rotterdam
Supervisors/Advisors
  • Kushner, Steven, Supervisor
  • Markx, S (Sander), Co-supervisor
Award date28 Sep 2021
Place of PublicationRotterdam
Publication statusPublished - 28 Sep 2021

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