Disease recurrence after colorectal cancer surgery in the modern era: a population-based study

Seyed M Qaderi*, Boris Galjart, Cornelis Verhoef, Gerrit D Slooter, Miriam Koopman, Robert H A Verhoeven, Johannes H W de Wilt, Felice N van Erning

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)
1 Downloads (Pure)

Abstract

PURPOSE: This population-based study determined the cumulative incidence (CI) of local, regional, and distant recurrences, examined metastatic patterns, and identified risk factors for recurrence after curative treatment for CRC.

METHODS: All patients undergoing resection for pathological stage I-III CRC between January 2015 and July 2015 and registered in the Netherlands Cancer Registry were selected (N = 5412). Additional patient record review and data collection on recurrences was conducted by trained administrators in 2019. Three-year CI of recurrence was calculated according to sublocation (right-sided: RCC, left-sided: LCC and rectal cancer: RC) and stage. Cox competing risk regression analyses were used to identify risk factors for recurrence.

RESULTS: The 3-year CI of recurrence for stage I, II, and III RCC and LCC was 0.03 vs. 0.03, 0.12 vs. 0.16, and 0.31 vs. 0.24, respectively. The 3-year CI of recurrence for stage I, II, and III RC was 0.08, 0.24, and 0.38. Distant metastases were found in 14, 12, and 16% of patients with RCC, LCC, and RC. Multiple site metastases were found often in patients with RCC, LCC, and RC (42 vs. 32 vs. 28%). Risk factors for recurrence in stage I-II CRC were age 65-74 years, pT4 tumor size, and poor tumor differentiation whereas in stage III CRC, these were ASA III, pT4 tumor size, N2, and poor tumor differentiation.

CONCLUSIONS: Recurrence rates in recently treated patients with CRC were lower than reported in the literature and the metastatic pattern and recurrence risks varied between anatomical sublocations.

Original languageEnglish
Pages (from-to)2399-2410
Number of pages12
JournalInternational Journal of Colorectal Disease
Volume36
Issue number11
Early online date4 Apr 2021
DOIs
Publication statusPublished - Nov 2021

Bibliographical note

© 2021. The Author(s).

Fingerprint

Dive into the research topics of 'Disease recurrence after colorectal cancer surgery in the modern era: a population-based study'. Together they form a unique fingerprint.

Cite this