Diversity and reassortment rate of influenza a viruses in wild ducks and gulls

Yulia Postnikova; Anastasia Treshchalina; Elizaveta Boravleva; Alexandra Gambaryan; Aydar Ishmukhametov; Mikhail Matrosovich; Ron A.M. Fouchier; Galina Sadykova; Alexey Prilipov; Natalia Lomakina

doi:10.3390/v13061010

Diversity and reassortment rate of influenza a viruses in wild ducks and gulls

Yulia Postnikova, Anastasia Treshchalina, Elizaveta Boravleva, Alexandra Gambaryan^*, Aydar Ishmukhametov, Mikhail Matrosovich, Ron A.M. Fouchier, Galina Sadykova, Alexey Prilipov, Natalia Lomakina

^*Corresponding author for this work

Virology

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Abstract

Influenza A viruses (IAVs) evolve via point mutations and reassortment of viral gene segments. The patterns of reassortment in different host species differ considerably. We investigated the genetic diversity of IAVs in wild ducks and compared it with the viral diversity in gulls. The complete genomes of 38 IAVs of H1N1, H1N2, H3N1, H3N2, H3N6, H3N8, H4N6, H5N3, H6N2, H11N6, and H11N9 subtypes isolated from wild mallard ducks and gulls resting in a city pond in Moscow, Russia were sequenced. The analysis of phylogenetic trees showed that stable viral genotypes do not persist from year to year in ducks owing to frequent gene reassortment. For comparison, similar analyses were carried out using sequences of IAVs isolated in the same period from ducks and gulls in The Netherlands. Our results revealed a significant difference in diversity and rates of reassortment of IAVs in ducks and gulls.

Original language	English
Article number	1010
Journal	Viruses
Volume	13
Issue number	6
DOIs	https://doi.org/10.3390/v13061010
Publication status	Published - Jun 2021

Bibliographical note

Funding Information:
Funding: This research was supported by the research grant 17-04-00148 from the Russian Foundation for Basic Research and by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)—Project number 197785619—SFB 1021. Publication was supported by Chumakov Federal Scientific Center for the Research and Development of Immune-and-Biological Products.

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© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

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Diversity and Reassortment Rate of Influenza A Viruses in Wild Ducks and GullsFinal published version, 870 KBLicence: CC BY

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title = "Diversity and reassortment rate of influenza a viruses in wild ducks and gulls",

abstract = "Influenza A viruses (IAVs) evolve via point mutations and reassortment of viral gene segments. The patterns of reassortment in different host species differ considerably. We investigated the genetic diversity of IAVs in wild ducks and compared it with the viral diversity in gulls. The complete genomes of 38 IAVs of H1N1, H1N2, H3N1, H3N2, H3N6, H3N8, H4N6, H5N3, H6N2, H11N6, and H11N9 subtypes isolated from wild mallard ducks and gulls resting in a city pond in Moscow, Russia were sequenced. The analysis of phylogenetic trees showed that stable viral genotypes do not persist from year to year in ducks owing to frequent gene reassortment. For comparison, similar analyses were carried out using sequences of IAVs isolated in the same period from ducks and gulls in The Netherlands. Our results revealed a significant difference in diversity and rates of reassortment of IAVs in ducks and gulls.",

author = "Yulia Postnikova and Anastasia Treshchalina and Elizaveta Boravleva and Alexandra Gambaryan and Aydar Ishmukhametov and Mikhail Matrosovich and Fouchier, {Ron A.M.} and Galina Sadykova and Alexey Prilipov and Natalia Lomakina",

note = "Funding Information: Funding: This research was supported by the research grant 17-04-00148 from the Russian Foundation for Basic Research and by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)—Project number 197785619—SFB 1021. Publication was supported by Chumakov Federal Scientific Center for the Research and Development of Immune-and-Biological Products. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

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doi = "10.3390/v13061010",

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AU - Postnikova, Yulia

AU - Treshchalina, Anastasia

AU - Boravleva, Elizaveta

AU - Gambaryan, Alexandra

AU - Ishmukhametov, Aydar

AU - Matrosovich, Mikhail

AU - Fouchier, Ron A.M.

AU - Sadykova, Galina

AU - Prilipov, Alexey

AU - Lomakina, Natalia

N1 - Funding Information: Funding: This research was supported by the research grant 17-04-00148 from the Russian Foundation for Basic Research and by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)—Project number 197785619—SFB 1021. Publication was supported by Chumakov Federal Scientific Center for the Research and Development of Immune-and-Biological Products. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/6

Y1 - 2021/6

N2 - Influenza A viruses (IAVs) evolve via point mutations and reassortment of viral gene segments. The patterns of reassortment in different host species differ considerably. We investigated the genetic diversity of IAVs in wild ducks and compared it with the viral diversity in gulls. The complete genomes of 38 IAVs of H1N1, H1N2, H3N1, H3N2, H3N6, H3N8, H4N6, H5N3, H6N2, H11N6, and H11N9 subtypes isolated from wild mallard ducks and gulls resting in a city pond in Moscow, Russia were sequenced. The analysis of phylogenetic trees showed that stable viral genotypes do not persist from year to year in ducks owing to frequent gene reassortment. For comparison, similar analyses were carried out using sequences of IAVs isolated in the same period from ducks and gulls in The Netherlands. Our results revealed a significant difference in diversity and rates of reassortment of IAVs in ducks and gulls.

AB - Influenza A viruses (IAVs) evolve via point mutations and reassortment of viral gene segments. The patterns of reassortment in different host species differ considerably. We investigated the genetic diversity of IAVs in wild ducks and compared it with the viral diversity in gulls. The complete genomes of 38 IAVs of H1N1, H1N2, H3N1, H3N2, H3N6, H3N8, H4N6, H5N3, H6N2, H11N6, and H11N9 subtypes isolated from wild mallard ducks and gulls resting in a city pond in Moscow, Russia were sequenced. The analysis of phylogenetic trees showed that stable viral genotypes do not persist from year to year in ducks owing to frequent gene reassortment. For comparison, similar analyses were carried out using sequences of IAVs isolated in the same period from ducks and gulls in The Netherlands. Our results revealed a significant difference in diversity and rates of reassortment of IAVs in ducks and gulls.

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Diversity and reassortment rate of influenza a viruses in wild ducks and gulls

Abstract

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