DNA damage and ageing: new-age ideas for an age-old problem

G Garinis; Bert van der Horst; J Vijg; Jan Hoeijmakers

doi:10.1038/ncb1108-1241

DNA damage and ageing: new-age ideas for an age-old problem

G Garinis, Bert van der Horst, J Vijg, Jan Hoeijmakers

Molecular Genetics

Research output: Contribution to journal › Article › Academic › peer-review

303 Citations (Scopus)

Abstract

Loss of genome maintenance may causally contribute to ageing, as exemplified by the premature appearance of multiple symptoms of ageing in a growing family of human syndromes and in mice with genetic defects in genome maintenance pathways. Recent evidence revealed a similarity between such prematurely ageing mutants and long-lived mice harbouring mutations in growth signalling pathways. At first sight this seems paradoxical as they represent both extremes of ageing yet show a similar 'survival' response that is capable of delaying age-related pathology and extending lifespan. Understanding the mechanistic basis of this response and its connection with genome maintenance would open exciting possibilities for counteracting cancer or age-related diseases, and for promoting longevity.

Original language	Undefined/Unknown
Pages (from-to)	1241-1247
Number of pages	7
Journal	Nature Cell Biology
Volume	10
Issue number	11
DOIs	https://doi.org/10.1038/ncb1108-1241
Publication status	Published - 2008

Research programs

EMC MGC-01-12-03

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/ncb1108-1241

http://hdl.handle.net/1765/14266

Cite this

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