DNA Double Strand Break Repair Pathways in Response to Different Types of Ionizing Radiation

Gerarda van de Kamp; Tim Heemskerk; Roland Kanaar; Jeroen Essers

doi:10.3389/fgene.2021.738230

DNA Double Strand Break Repair Pathways in Response to Different Types of Ionizing Radiation

Gerarda van de Kamp, Tim Heemskerk, Roland Kanaar, Jeroen Essers^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › Academic › peer-review

10 Citations (Scopus)

30 Downloads (Pure)

Abstract

The superior dose distribution of particle radiation compared to photon radiation makes it a promising therapy for the treatment of tumors. However, the cellular responses to particle therapy and especially the DNA damage response (DDR) is not well characterized. Compared to photons, particles are thought to induce more closely spaced DNA lesions instead of isolated lesions. How this different spatial configuration of the DNA damage directs DNA repair pathway usage, is subject of current investigations. In this review, we describe recent insights into induction of DNA damage by particle radiation and how this shapes DNA end processing and subsequent DNA repair mechanisms. Additionally, we give an overview of promising DDR targets to improve particle therapy.

Original language	English
Article number	738230
Journal	Frontiers in Genetics
Volume	12
DOIs	https://doi.org/10.3389/fgene.2021.738230
Publication status	Published - 30 Sept 2021

Bibliographical note

Funding Information:
This work was supported by the Dutch Cancer Society (INTO-PROT, 12092/2018) and Varian (PROTON-DDR, 2019020), and is part of the Oncode Institute, which was partly financed by the Dutch Cancer Society.

Publisher Copyright:
© Copyright © 2021 van de Kamp, Heemskerk, Kanaar and Essers.

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fgene-12-738230Final published version, 1.72 MBLicence: CC BY

Cite this

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abstract = "The superior dose distribution of particle radiation compared to photon radiation makes it a promising therapy for the treatment of tumors. However, the cellular responses to particle therapy and especially the DNA damage response (DDR) is not well characterized. Compared to photons, particles are thought to induce more closely spaced DNA lesions instead of isolated lesions. How this different spatial configuration of the DNA damage directs DNA repair pathway usage, is subject of current investigations. In this review, we describe recent insights into induction of DNA damage by particle radiation and how this shapes DNA end processing and subsequent DNA repair mechanisms. Additionally, we give an overview of promising DDR targets to improve particle therapy.",

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AB - The superior dose distribution of particle radiation compared to photon radiation makes it a promising therapy for the treatment of tumors. However, the cellular responses to particle therapy and especially the DNA damage response (DDR) is not well characterized. Compared to photons, particles are thought to induce more closely spaced DNA lesions instead of isolated lesions. How this different spatial configuration of the DNA damage directs DNA repair pathway usage, is subject of current investigations. In this review, we describe recent insights into induction of DNA damage by particle radiation and how this shapes DNA end processing and subsequent DNA repair mechanisms. Additionally, we give an overview of promising DDR targets to improve particle therapy.

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DNA Double Strand Break Repair Pathways in Response to Different Types of Ionizing Radiation

Abstract

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