DNA repair by the MRN complex: Break it to make it

Roland Kanaar; C.L. Wyman

doi:10.1016/j.cell.2008.09.027

DNA repair by the MRN complex: Break it to make it

Roland Kanaar, C.L. Wyman

Research output: Contribution to journal › Article › Academic › peer-review

26 Citations (Scopus)

Abstract

Genomic instability in ataxia telangiectasia-like disorder and Nijmegen breakage syndrome is due to disruption of the Mre11-Rad50-Nbs1 complex. Buis et al. (2008) and Williams et al. (2008) now reveal the importance of the nuclease activity of Mre11 for mammalian genome maintenance and present a molecular view of its active site.

Original language	Undefined/Unknown
Pages (from-to)	14-16
Number of pages	3
Journal	Cell
Volume	135
Issue number	1
DOIs	https://doi.org/10.1016/j.cell.2008.09.027
Publication status	Published - 2008

Access to Document

10.1016/j.cell.2008.09.027

http://hdl.handle.net/1765/28801

Cite this

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title = "DNA repair by the MRN complex: Break it to make it",

abstract = "Genomic instability in ataxia telangiectasia-like disorder and Nijmegen breakage syndrome is due to disruption of the Mre11-Rad50-Nbs1 complex. Buis et al. (2008) and Williams et al. (2008) now reveal the importance of the nuclease activity of Mre11 for mammalian genome maintenance and present a molecular view of its active site.",

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AU - Wyman, C.L.

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AB - Genomic instability in ataxia telangiectasia-like disorder and Nijmegen breakage syndrome is due to disruption of the Mre11-Rad50-Nbs1 complex. Buis et al. (2008) and Williams et al. (2008) now reveal the importance of the nuclease activity of Mre11 for mammalian genome maintenance and present a molecular view of its active site.

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DO - 10.1016/j.cell.2008.09.027

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