DNA repair by the MRN complex: Break it to make it

Roland Kanaar, C.L. Wyman

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Scopus)

Abstract

Genomic instability in ataxia telangiectasia-like disorder and Nijmegen breakage syndrome is due to disruption of the Mre11-Rad50-Nbs1 complex. Buis et al. (2008) and Williams et al. (2008) now reveal the importance of the nuclease activity of Mre11 for mammalian genome maintenance and present a molecular view of its active site.
Original languageUndefined/Unknown
Pages (from-to)14-16
Number of pages3
JournalCell
Volume135
Issue number1
DOIs
Publication statusPublished - 2008

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