Does HPA-axis activity mediate the relationship between obstetric complications and externalizing behavior problems? The TRAILS study

R Marsman, JGM (Judith) Rosmalen, AJ (A.) Oldehinkel, J Ormel, JK Buitelaar

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Abstract

To examine whether HPA-axis activity mediates the relationship between obstetric complications (OCs) and externalizing behavior problems, and to investigate whether this model is different for boys and girls. In a population-based cohort of 1,768 10- to 12-year-old early adolescents, we assessed the cortisol awakening response and evening cortisol levels. Externalizing behavior problems were assessed using the Child Behavior Checklist and the Youth Self-Report. OCs were retrospectively assessed in a parent interview. OCs significantly predicted externalizing behavior problems, but OCs did not predict HPA-axis activity. Thus, the mediation model was not supported. In addition to the relationship between HPA-axis activity and externalizing behavior problems, which is specific for girls, there is also a relationship between OCs and externalizing behavior problems. However, these two mechanisms are not related to each other indicating that HPA-axis activity is not a mediator in the relationship between OCs and externalizing behavior problems. Future research should focus on understanding the mechanism through which OCs cause externalizing behavior problems.
Original languageUndefined/Unknown
Pages (from-to)565-573
Number of pages9
JournalEuropean Child & Adolescent Psychiatry
Volume18
Issue number9
DOIs
Publication statusPublished - 2009

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