Dosimetry of ¹³¹I treatment in differentiated thyroid cancer

I-131 therapy, also known as radioiodine therapy (RIT), is a proven highly effective treatment for patients with differentiated thyroid cancer (DTC) I-131 is usually dosage through fixed activities which may be adapted to fit the clinical stage without further individualization. The low, but significant potential risk of late adverse events associated with the administration of radioiodine as well the potential for under treatment using such simple regimes leave significant potential for improvement of therapy through individualization by means of individual dosimetry. In this chapter the potential indications, methods, concepts of safety-based and efficacy based dosimetry strategies and limitations of dosimetry of I-131 treatment in differentiated thyroid cancer will be reviewed.