Dossiervoering van farmacogenetische uitslagen: Een implementatieonderzoek in de Haagse regio

BACKGROUND: Pharmacogenetic testing is becoming increasingly important as it is used in prevention of severe adverse drug reactions, and for optimization of pharmacological therapy for patients with an unexpected response to drugs. In our health care system pharmacogenetics has been introduced since a couple of years. However, the traceability of the pharmacogenetics status in electronic patient files is limited. OBJECTIVE: To assess, improve and evaluate the process of recording information on the patient's pharmacogenetic status within the hospital setting. METHODS: This implementation survey was conducted in two hospitals in The Hague, with an assessment before implementation of structural recording of the pharmacogenetic status in 2015 and an evaluation after implementation in 2017. All patients with a request for pharmacogenetic testing by a physician affiliated with one of the hospitals were included. For each patient we collected data in electronic patient files. The primary outcome was the percentage of patients with a registration of the pharmacogenetic result, both wild-type and mutation, in the hospital information system on patient level. RESULTS: Of the 193 patients included, none (0%) had their pharmacogenetic results reported in the hospital information system prior to implementation, compared to respectively 94,4% (17 of 18 patients) of the Haaglanden Medisch Centrum and 58.3% (42 of 72 patients) of the HagaZiekenhuis after implementation. CONCLUSION: In this study 94,4% of the patients from the Haaglanden Medisch Centrum and 58,3% of the patients from the HagaZiekenhuis, had their pharmacogenetic status available in the hospital information system after implementation. Further revisions and research is needed to optimise the process and determine the influence on medication safety.