Down syndrome acute lymphoblastic leukemia and beyond: Genetics, prognosis, and new therapeutic optionsDown

Naomi Michels

Research output: Types of ThesisDoctoral ThesisInternal

4 Downloads (Pure)

Abstract

Children with Down syndrome have an increased risk of developing acute lymphoblastic leukemia. These children are also known to have a higher risk of relapse and treatment related toxicity. This thesis focused on treatment outcomes and prognostic factors of children with Down syndrome and acute lymphoblastic leukemia. Additionally, this thesis investigated the frequency of targetable lesions in children with Down syndrome acute lymphoblastic leukemia. Finally, this thesis includes the results of a phase 2 clinical trial with inotuzumab ozogamicin monotherapy for children with acute lymphoblastic leukemia but without Down syndrome, which will hopefully attribute to the eligibility of these treatments for children with Down syndrome as well.
Original languageEnglish
Awarding Institution
  • Erasmus University Rotterdam
Supervisors/Advisors
  • Zwaan, C. Michel, Supervisor
  • den Boer, Monique, Supervisor
  • Boer, Judith, Co-supervisor
Award date2 Oct 2024
Place of PublicationRotterdam
Print ISBNs978-94-6510-105-7
Publication statusPublished - 2 Oct 2024

Fingerprint

Dive into the research topics of 'Down syndrome acute lymphoblastic leukemia and beyond: Genetics, prognosis, and new therapeutic optionsDown'. Together they form a unique fingerprint.

Cite this