Drug clearance by continuous haemodiafiltration: Analysis of sieving coefficients and mass transfer coefficients of diffusion

H. H. Vincent*, M. C. Vos, E. Akçahuseyin, W. H.F. Goessens, W. A. van Duyl, M. A.D.H. Schalekamp

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

41 Citations (Scopus)

Abstract

In patients who were treated with continuous arteriovenous haemodiafiltration (CAVHD), using the AN-69 capillary dia- lyser, we measured the clearance rates of uraemic solutes and drugs at dialysate flow rates of 0, 1 and 3 1/h. By using a mathematical model of CAVHD, we analysed the data in terms of sieving coefficients and diffusive mass transfer coefficients. These parameters proved to be related to drug protein binding and molecular weight. The parameter values may be used to calculate the expected drug clearance rate under different operating conditions.

Original languageEnglish
Pages (from-to)99-107
Number of pages9
JournalBlood Purification
Volume11
Issue number2
DOIs
Publication statusPublished - 1993

Bibliographical note

© 1993 S. Karger AG, Basel

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