Drug Susceptibility of Mycobacterium tuberculosis Beijing Genotype and Association with MDR TB

Jurriaan de Steenwinkel; Marian ten Kate; Gerjo Knegt; K Kremer; RE Aarnoutse; MJ Boeree; Henri Verbrugh; D van Soolingen; Irma Woudenberg

doi:10.3201/eid1804.110912

Drug Susceptibility of Mycobacterium tuberculosis Beijing Genotype and Association with MDR TB

Jurriaan de Steenwinkel, Marian ten Kate, Gerjo Knegt, K Kremer, RE Aarnoutse, MJ Boeree, Henri Verbrugh, D van Soolingen, Irma Woudenberg

Medical Microbiology & Infectious Diseases

Research output: Contribution to journal › Article › Academic › peer-review

90 Citations (Scopus)

Abstract

To determine differences in the ability of Mycobacterium tuberculosis strains to withstand antituberculosis drug treatment, we compared the activity of antituberculosis drugs against susceptible Beijing and East-African/Indian genotype M. tuberculosis strains. Beijing genotype strains showed high rates of mutation within a wide range of drug concentrations, possibly explaining this genotype's association with multidrug-resistant tuberculosis.

Original language	Undefined/Unknown
Pages (from-to)	660-663
Number of pages	4
Journal	Emerging Infectious Diseases
Volume	18
Issue number	4
DOIs	https://doi.org/10.3201/eid1804.110912
Publication status	Published - 2012

Research programs

EMC MM-04-28-01

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3201/eid1804.110912

Cite this

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abstract = "To determine differences in the ability of Mycobacterium tuberculosis strains to withstand antituberculosis drug treatment, we compared the activity of antituberculosis drugs against susceptible Beijing and East-African/Indian genotype M. tuberculosis strains. Beijing genotype strains showed high rates of mutation within a wide range of drug concentrations, possibly explaining this genotype's association with multidrug-resistant tuberculosis.",

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AU - de Steenwinkel, Jurriaan

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AU - Knegt, Gerjo

AU - Kremer, K

AU - Aarnoutse, RE

AU - Boeree, MJ

AU - Verbrugh, Henri

AU - van Soolingen, D

AU - Woudenberg, Irma

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AB - To determine differences in the ability of Mycobacterium tuberculosis strains to withstand antituberculosis drug treatment, we compared the activity of antituberculosis drugs against susceptible Beijing and East-African/Indian genotype M. tuberculosis strains. Beijing genotype strains showed high rates of mutation within a wide range of drug concentrations, possibly explaining this genotype's association with multidrug-resistant tuberculosis.

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DO - 10.3201/eid1804.110912

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