Durability of immune responses after boosting in Ad26.COV2.S-primed healthcare workers

Roos S G Sablerolles, Wim J R Rietdijk, Abraham Goorhuis, Douwe F Postma, Leo G Visser, Katharina S Schmitz, Daryl Geers, Susanne Bogers, Eva van Haren, Marion P G Koopmans, Virgil A S H Dalm, Neeltje A Kootstra, Anke L W Huckriede, Renate Akkerman, Martin Beukema, Melvin Lafeber, Debbie van Baarle, Rory D de Vries, P Hugo M van der Kuy, Corine H GeurtsvanKessel*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

The emergence of SARS-CoV-2 variants raised questions regarding the durability of immune responses after homologous or heterologous booster vaccination after Ad26.COV2.S priming. We found that SARS-CoV-2-specific binding antibodies, neutralizing antibodies and T-cells are detectable 5 months after boosting, although waning of antibodies and limited cross-reactivity with Omicron BA.1 was observed.

Original languageEnglish
Article numberciac495
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America
DOIs
Publication statusE-pub ahead of print - 20 Jun 2022

Bibliographical note

© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

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