Early body weight loss during concurrent chemo-radiotherapy for non-small cell lung cancer

Céline M.H. Op den Kamp, Dirk K.M. De Ruysscher, Marieke van den Heuvel, Meike Elferink, Ruud M.A. Houben, Cary J.G. Oberije, Gerben P. Bootsma, Wiel H. Geraedts, Cordula C.M. Pitz, Ramon C. Langen, Emiel F.M. Wouters, Annemie M.W.J. Schols, Anne Marie C. Dingemans*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)
8 Downloads (Pure)

Abstract

Background and purpose: Radiation-esophagitis and weight loss are frequently observed toxicities in patients treated with concurrent chemo-radiotherapy (CT-RT) for non-small cell lung cancer (NSCLC) and might be related. The purpose was to investigate whether weight loss already starts early after initiation of CT-RT and precedes radiation-esophagitis. Materials and methods: In a retrospective cohort, weight and esophagitis grade ≥2 were assessed during the first weeks of (CT-)RT in patients treated with concurrent (n = 102) or sequential (n = 92) therapy. In a prospective validation study, data on body weight, esophagitis grade ≥2, nutritional intake and muscle strength were obtained before, during and following CT-RT. Results: In the retrospective cohort, early weight loss was observed in concurrently treated patients (p = 0.002), independent of esophagitis ≥ grade 2. Early weight loss was also observed in the prospective cohort (p = 0.003) and was not accompanied by decreases in nutritional intake. In addition lower limb muscle strength rapidly declined (p = 0.042). In the later weeks of treatment, further body weight loss occurred (p < 0.001) despite increased nutritional supplementation and body weight was only partly recovered after 4 weeks post CT-RT (p = 0.003). Conclusions: Weight loss during concurrent CT-RT for NSCLC starts early and prior to onset of esophagitis, requiring timely and intense nutritional rehabilitation.

Original languageEnglish
Pages (from-to)127-137
Number of pages11
JournalJournal of Cachexia, Sarcopenia and Muscle
Volume5
Issue number2
DOIs
Publication statusPublished - Jun 2014
Externally publishedYes

Bibliographical note

#Springer-Verlag Berlin Heidelberg 2014

Fingerprint

Dive into the research topics of 'Early body weight loss during concurrent chemo-radiotherapy for non-small cell lung cancer'. Together they form a unique fingerprint.

Cite this