TY - JOUR
T1 - Early brain magnetic resonance imaging findings and neurodevelopmental outcome in children with congenital heart disease
T2 - A systematic review
AU - Dijkhuizen, Emma I
AU - de Munck, Sophie
AU - de Jonge, Rogier C J
AU - Dulfer, Karolijn
AU - van Beynum, Ingrid M
AU - Hunfeld, Maayke
AU - Rietman, André B
AU - Joosten, Koen F M
AU - van Haren, Neeltje E M
N1 - Publisher Copyright:
© 2023 The Authors. Developmental Medicine & Child Neurology published by John Wiley & Sons Ltd on behalf of Mac Keith Press.
PY - 2023/4/10
Y1 - 2023/4/10
N2 - AIM: To investigate the association between early brain magnetic resonance imaging (MRI) findings and neurodevelopmental outcome (NDO) in children with congenital heart disease (CHD).METHOD: A search for studies was conducted in Embase, Medline, Web of Science, Cochrane Central, PsycINFO, and Google Scholar. Observational and interventional studies were included, in which patients with CHD underwent surgery before 2 months of age, a brain MRI scan in the first year of life, and neurodevelopmental assessment beyond the age of 1 year.RESULTS: Eighteen studies were included. Thirteen found an association between either quantitative or qualitative brain metrics and NDO: 5 out of 7 studies showed decreased brain volume was significantly associated with worse NDO, as did 7 out of 10 studies on brain injury. Scanning protocols and neurodevelopmental tests varied strongly.INTERPRETATION: Reduced brain volume and brain injury in patients with CHD can be associated with impaired NDO, yet standardized scanning protocols and neurodevelopmental assessment are needed to further unravel trajectories of impaired brain development and its effects on outcome.
AB - AIM: To investigate the association between early brain magnetic resonance imaging (MRI) findings and neurodevelopmental outcome (NDO) in children with congenital heart disease (CHD).METHOD: A search for studies was conducted in Embase, Medline, Web of Science, Cochrane Central, PsycINFO, and Google Scholar. Observational and interventional studies were included, in which patients with CHD underwent surgery before 2 months of age, a brain MRI scan in the first year of life, and neurodevelopmental assessment beyond the age of 1 year.RESULTS: Eighteen studies were included. Thirteen found an association between either quantitative or qualitative brain metrics and NDO: 5 out of 7 studies showed decreased brain volume was significantly associated with worse NDO, as did 7 out of 10 studies on brain injury. Scanning protocols and neurodevelopmental tests varied strongly.INTERPRETATION: Reduced brain volume and brain injury in patients with CHD can be associated with impaired NDO, yet standardized scanning protocols and neurodevelopmental assessment are needed to further unravel trajectories of impaired brain development and its effects on outcome.
UR - http://www.scopus.com/inward/record.url?scp=85152272781&partnerID=8YFLogxK
U2 - 10.1111/dmcn.15588
DO - 10.1111/dmcn.15588
M3 - Review article
C2 - 37035939
SN - 0012-1622
JO - Developmental Medicine and Child Neurology
JF - Developmental Medicine and Child Neurology
ER -